事件相关电位p300在精神分裂症并发代谢综合征患者中的变化研究

Effect of event related potential p300 in schizophrenia complicated with metabolic syndrome

目的探讨事件相关电位p300在精神分裂症(Sch)并发代谢综合征(MS)患者中的变化。方法采用连续取样法,选取2014年9月至2015年10月期间就诊的Sch患者165例,80例符合MS诊断标准的病例作为研究组,按就诊序号取前85例不符合MS诊断标准的病例设为对照组。全部患者均测定腰围、体质量指数(BMI)、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白(HDL)、收缩压(SBP)、舒张压(DBP)、事件相关电位p300水平,采用蒙特利尔认知评估量表(MOCA)评定认知功能。结果研究组腰围、BMI、FBG、TG、SBP、DBP均明显高于对照组,HDL水平明显低于对照组,组间比较差异有统计学意义(P<0.05)。研究组OZ、PZ、CZ、FZ点N2、P3波幅明显低于对照组,各点N2、P3潜伏期明显长于对照组,组间比较差异有统计学意义(P<0.05)。研究组MOCA评分明显低于对照组,组间比较差异有统计学意义(P<0.05)。结论事件相关电位p300在精神分裂症并发代谢综合征患者中异常改变,p300波幅缩短,潜伏期延长可能与机体代谢及认知功能异常改变有关。

Objective To observe the change of event related potential p300 in schizophrenia complicated with metabolic syndrome（ MS）.Methods The continuous sampling method was adopted.165 cases of schizophrenia patients were selected in this study,in which 80 patients met the diagnostic criteria of MS as the research group,and 85 patients did not meet the diagnostic criteria of MS as the control group.The waistline,body mass index（ BMI）, fasting plasma glucose（ FPG）, triglyceride（ TG）, high- density lipoprotein（ HDL）, systolic blood pressure（ SBP）, diastolic blood pressure（ DBP） and event related potential p300 levels of all patients were measured.The cognitive function was evaluated by Montreal cognitive assessment scale（ MOCA）.Results Compared with the control group,the waistline,BMI,FBG,TG,SBP and DBP were significantly increased,but HDL was lower,in the research group（ P〈0.05）.N2 and P3 amplitude in OZ,PZ,CZ and FZ point were obviously decreased,but each point of N2 and P3 latent period were longer,in the research group（ P〈0.05）.MOCA score was significantly lower in the research group（ P〈0.05）.Conclusion Event related potential p300 plays an important role in predicting the occurrence of schizophrenia,in which p300 amplitude shortening and latency prolongation may be related to the changes of body metabolism and cognitive function.