C5b-9在胃腺癌中表达与疾病的相关性研究

Relevant research on expression of C5b-9 and disease in gastric adenocarcinoma

目的探讨补体活化片段C5b-9表达与胃腺癌发病之间的相关性。方法运用组织芯片和免疫组织化学的方式对32例胃腺癌患者癌及癌旁组织C5b-9的表达进行检测,并用多项逻辑回归和似然比的方法对结果进行分析,评估相关性。结果补体C5b-9的表达与胃腺癌疾病的临床分期(P=0.007)和TNM分期(P=0.005)密切相关,但与年龄、性别及转移程度等因素没有明显关联。结论补体C5b-9或可作为临床中诊断胃腺癌疾病分期的标准,为诊断、评估及治疗胃腺癌提供理论依据。

Objective To evaluate the correlation between the expression of C5b-9 and the gastric carcinoma.Methods In this study, the human gastric adenocarcinoma （HGAC）tissues （n =32 cases）from 32 patients were evaluated by immunohistochemistry and tissue chip.The result was analyzed and evaluated by Multinomial logistic regression and likelihood ratio.Results Multinomial logistic regression and likelihood ratio testing showed that over-expression of C5b-9 in HGAC tissue was significantly correlated with clinical stage （P =0.007） and tumor stage （P =0.005）,but not with tumor metastasis,lymphoid nodal status,sex or age.Conclusion C5b-9 can be the criteria of di-agnosis and clinical staging for gastric adenocarcinoma,which may help in diagnosis and assessment disease severity of human gastric carcinoma.