选择性多聚腺苷酸化在生物学过程中功能的研究进展

Research advances on the function of alternative polyadenylation in biological processes

选择性多聚腺苷酸化(alternative polyadenylation,APA)在基因表达调控、发育、分化、转化和增殖过程中具有重要作用。文章综述了APA在细胞激活与增殖、发育和分化代谢调控中的功能,同时也综述了microRNAs和APA相互作用的调控网络关系,对了解APA对真核生物的生命活动具有重要的生物学意义。

Ahernative polyadenylation （APA） plays an important role in the processes of gane expression regulation, development, differentia- tion, transformation, and proliferation. This paper reviews the functions of APA in the regulation of cell activation and proliferation, develop- ment and differentiation. At the same time, the paper also summarizes the regulatory network relationship of interactions between microRNAs and APA, which has important biological significance in understanding APA for life activities in eukaryotes.