盐酸帕罗西汀合并奥氮平治疗强迫症的效果分析

Effects analysis of paroxetine hydrochloride combined with olanzapine in treating obsessive-compulsive disorder

目的 分析盐酸帕罗西汀联合奥氮平治疗强迫症的可行性及安全性。方法 选取2013年2月~2016年2月我院精神心理门诊诊治的82例强迫症患者,根据不同的治疗方法将其分为观察组与对照组,每组41例。对照组采用盐酸帕罗西汀片进行治疗,观察组在对照组的基础上加用奥氮平进行治疗。对两组患者的治疗效果与不良反应采用耶鲁-布朗强迫症状量表（Y-BOCS）、汉密尔顿焦虑量表（HAMA）以及不良反应发生情况进行对比分析。结果 观察组与对照组总有效率分别为87.80%（36/41）及69.29%（28/41）,差异有统计学意义（P〈0.05）;在治疗第2个月时,观察组的HAMA及Y-BOCS显著低于对照组,差异有统计学意义（P〈0.05）;两组患者治疗前、后血糖血脂情况比较,差异无统计学意义（P〉0.05）;同时两组患者均有消化道反应以及胃部不适,经对症处理均可缓解（P〉0.05）。结论 采用盐酸帕罗西汀合并奥氮平治疗强迫症效果显著,安全可靠,是一种有效的治疗方法,值得临床推广应用。

Objective To analyze the feasibility and safety of paroxetine hydrochloride combined with olanzapine in treating obsessive-compulsive disorder.Methods 82 patients in mental and psychological clinic of our hospital from February 2013 to February 2016 were selected and divided into observation group and control group according to differ- ent treatment methods,and each group was 41 cases.Patients in the control group were used paroxetine hydrochloride, and patients in the observation group were used olanzapine on the basis of control group.The treatment effects and ad- verse effects in two groups were compared by using Y-BOCS and the incidence of adverse effects in two groups was compared by using HAMA.Results The total effective rate in the observation group and the control group was respec- tively 87.80% （36/41） and 69.29% （28/41）,and the difference was statistical significance （P〈0.05）;in the treatment for the 2~ months,HAMA and Y-BOCS in the observation group were lower than those in the control group,and the differ- ence was statistical significance （P〈0.05）;the blood glucose and blood lipid in two groups before and after treatment had no difference （P〉0.05）;at the same time,patients in two groups had gastrointestinal reaction and stomach discomfort,and symptomatic treatment eased （P〉0.05）.Conclusion Paroxetine hydrochloride combined with olanzapine in treating ob- sessive-compulsive disorder has obvious effects and with safety,which is an effective method and is worth popularize and application in clinic.