喹诺酮类抗菌药物临床应用的药学干预方法及意义探析

Analysis on the significance and method of pharmaceutical intervention of quinolones antibacterial drugs in clinical application

目的 分析喹诺酮类抗菌药物临床应用的药学干预方法 ,并探讨药学干预在喹诺酮类抗菌药物临床应用中的价值。方法 选取2014年1~12月我院未进行药学干预期间的2000张喹诺酮类抗菌药物处方作为对照组,另选取2015年1~12月我院进行药学干预后的2000张喹诺酮类抗菌药物处方作为观察组。对照组未进行药学干预,对其处方进行点评,对不合格处方进行总结分析;观察组根据对照组阶段的不合格处方出现原因实施相应的药学干预。比较两组的处方不合格率、喹诺酮类药物使用频率、药物利用指数。结果 观察组的处方不合格率为9.10%,显著低于对照组的12.85%,差异有统计学意义（P〈0.05）。观察组的药物使用频率、药物利用指数显著低于对照组,差异有统计学意义（P〈0.05）。结论 根据喹诺酮类抗菌药物的不合理用药原因实施有针对性的药学干预,可有效减少药物的不合理应用情况,提高药物的利用率。

Objective To analyze the pharmacy intervention methods of quinolones antibacterial drugs clinical application,and to explore the value of pharmaceutical intervention in quinolone antibacterial drugs in clinical application. Methods 2000 cases of quinolone antibiotic prescription from January to December in 2014 in our hospital without pharmaceutical intervention were selected as the control group,and 2000 pieces of quinolone antibacterial drugs prescription from January to December in 2015 in our hospital with pharmaceutical intervention were selected as the ob- servation group.The control group had not carried out pharmaceutical intervention,the prescription was reviewed,the un- qualified prescriptions were summarized and analyzed.The observation group had implemented the corresponding drug intervention according to the reasons of the control group.The unqualified prescription rate,frequency of use of quinolones drugs,drug utilization index was compared between the two groups.Results The unqualified prescription rate in the observation group was 9.10%,which was lower than 12.85% in the control group,with significant difference （P〈 0.05）.The frequency of use of quinolones drugs,drug utilization index in the observation group was lower than that in the control group,with significant difference （P〈0.05）.Conclusion According to quinolone antibacterial drugs of irrational drug use causes implementation for pharmaceutical intervention can effectively reduce the unreasonable drug application,improve drug utilization rate.