头孢哌酮钠/舒巴坦钠(舒普深)治疗老年人肺部感染的临床分析

Clinical analysis of Cefoperazone sodium/Sulbactam sodium(Shupushen) in the treatment of pulmonary infection in the elderly patients

目的 探讨头孢哌酮钠/舒巴坦钠（舒普深）治疗老年肺部感染的临床效果。方法 回顾性分析我院2012年3月~2015年1月就诊的200例老年人肺部感染患者的临床资料,根据治疗方式的不同将其分为左克组和舒普深组,各100例。左克组采用盐酸左氧氟沙星注射液（左克）进行治疗,舒普深组采用舒普深进行治疗。比较两组的治疗总有效率、药物副作用发生率以及干预前后的IL-6、CRP、WBC、TNF-α水平。结果 两组的肺部感染治疗总有效率比较,差异无统计学意义（P〉0.05）。舒普深组干预后的IL-6、CRP、WBC、TNF-α水平显著优于左克组,差异有统计学意义（P〈0.05）。舒普深组的药物副作用发生率显著低于左克组,差异有统计学意义（P〈0.01）。结论 舒普深治疗老年人肺部感染临床效果确切,可有效改善临床症状,减轻机体炎症水平,且副作用更少,安全性更高,值得临床推广应用。

Objective To explore the clinical effect of Cefoperazone sodium/Sulbactam sodium （Shupushen） in the treatment of pulmonary infection in the elderly patients.Methods Clinical data of 200 cases of elderly patients with pulmonary infection in our hospital from March 2012 to January 2015 were retrospective analyzed.According to the differ- ent treatment methods,all patients were divided into the Zuoke group and the Shupushen group,100 cases in each group.The Zuoke group was given Levofloxacine hydrochloride injection （Zuoke）,the Shupushen group was given Shu- pushen.The total effective rate,the incidence rate of side effects of drugs and the level of IL-6,CRP,WBC and TNF-ct before and after the intervention was compared between the two groups respectively.Results There was no significant difference in the total effective rate between the two groups in the treatment of pulmonary infection （P〉0.05）.The level of IL-6,CRP,WBC and TNF-a after the intervention in the Shupushen group was better than that in the Zuoke group, with significant difference （P〈O.05）.The incidence rate of side effects of drugs in the Shupushen group was lower than that in the Zuoke group,with significant difference （P〈0.01）.Conclusion Clinical effect of Shupushen in the treatment of pulmonary infection in the elderly patients is exact,which can effectively improve clinical symptoms,reduce the level of infammation of the body,and less side effects,higher safety,it is worthy of clinical promotion and application.