8、18、30个月小儿骨源性碱性磷酸酶结果分析

Analysis on the results of neonatal bone alkaline phosphatase in children with 8,18,30 months

目的 分析8、18、30个月小儿骨源性碱性磷酸酶（NBAP）的检测结果 。方法 对2015年5~10月大连市普兰店区妇幼保健院儿童保健门诊体检的2640例8、18、30个月小儿进行NBAP活性检测,根据原卫生部颁发的婴幼儿佝偻病防治方案进行佝偻病临床筛查。并对NBAP检测结果异常者进行治疗后复查,观察NBAP值的变化情况。结果 月龄越小,佝偻病检出率越高,NBAP可疑率为77.3%,以NBAP≥250 U/L为佝偻病界限值,患病率为15.1%。男童阳性预防水平和阳性异常检出率稍高于女童,差异无统计学意义（χ2=1.06,P〉0.05）。居住在乡镇的婴幼儿阳性预防水平和阳性异常检出率明显高于居住在城市的婴幼儿,差异有统计学意义（χ2=124.00,P〈0.01）。治疗组有效率为76.33%,高于对照组的37.37%,两组比较差异有统计学意义（χ2=32.97,P〈0.01）。结论 小儿NBAP是佝偻病早期诊断的可靠指标,也是判断治疗效果的监测指标。

Objective To analyze the detection results of bone alkaline phosphatase （NBAP） in children with 8,18,30 months.Methods NBAP of 2640 cases of 8,18,30 months Pulandian children who medicated in maternal and child health care hospital of Dalian city from May to October 2015 were detected,according to the former Ministry of Health issued the infant rickets prevention scheme for clinical screening for rickets.And NBAP test results were abnormal after treatment review,the change of NBAP value was observed.Results The age smaller,the higher the incidence of rickets, NBAP suspicious rate was 77.3%,rickets limit value of NBAP was equal to or larger than 250 U/L,the prevalence rate of 15.1%.The positive rate of prevention and abnormal positive rate of boys was slightly higher than that of girls, the difference was not statistically significant （x^=1.06,P〉0.05）.The positive rate of infants and young children living in the villages and towns was significantly higher than that in the city,and the difference was statistically significant （x^2= 124.00,P〈0.01）.The effective rate of the treatment group was 76.33%,higher than 37.37% of the control group,the difference was statistically significant（x^2=32.97,P〈0.01）.Conclusion NBAP is a reliable indicator for the early diagnosis of infantile rickets, but also determine the monitoring index of treatment effect.