代谢综合征对良性前列腺增生患者临床进展性的影响

Impact of metabolic syndrome on clinical progression of patients with benign prostatic hyperplasia

目的:探讨代谢综合征(MS)对良性前列腺增生(BPH)患者临床进展的影响。方法:回顾性分析BPH患者241例,分析MS及其各组份包括:体质量指数(BMI)、腰臀比(WHR)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)与BPH之间的相关性。结果:在BPH患者临床进展分组中低进展组(LPG)、低进展组-1(LPG-1)、低进展组-2(LPG-2)和高进展组(HPG)患者的SBP、TG、TC、HDL-C、LDL-C检验差异有统计学意义(P<0.05);前列腺体积(PV)与TG、TC、LDL-C呈正相关,与HDL-C呈负相关(P<0.05);国际前列腺症状评分(IPSS)与年龄、WHR、SBP、DBP呈正相关(P<0.05);生活质量评分(QOL)与WHR、DBP、SBP呈正相关(P<0.05);最大尿流率(Qmax)与年龄呈负相关(P<0.05);年龄、WHR、SBP与储尿期症状、排尿期症状、排尿后症状均呈正相关(P<0.05);DBP与储尿期症状呈正相关(P<0.05)。结论:MS及其组份是诱发BPH的危险因素,且能够促进BPH的发生及临床进展。

Objective To investigate impact of metabolic syndrome （MS） on clinical progression of patients with benign pros-tatic hyperplasia （BPH）. Methods： 241 patients in the urinar^^ department of Jilin central hospital were collected, divided into low progression group （LPG） , low progression group -1 （ LPG -1）, low progression group -2 （ LPG -2） and high progression group （HPG） , and retrospectively analyzed. The correlations among BPH and MS and its components like body mass index （BMI） , waist- to-hip ratio （WHR） , waist circumference （WC） , systolic blood pressure （ SBP） , diastolic blood pressure （ DBP） , fasting plasma glucose （FPG） , triglyceride （TG） , total cholesterol （TC） , high-density lipoprotein （HDL-C） , and low-density lipoprotein （LDL- C） were analyzed. Results： There were statistical differences in the SBP, TG, TC, HDL-C and LDL-C among the LPG, LPG-1 , LPG-2 and HPG （ P〈0. 05）. The prostate volume （PV） was positively correlated with TG, TC and LDL-C, and negatively correlated with HDL-C （P〈0.05）. The international prostate symptom score （IPSS） was positively correlated with age, WHR, SBP and DBP （P〈0. 05）. The quality of life （ QOL） score was positively correlated with WHR, SBP and DBP （P〈0. 05 ）. The Qmax was negatively correlated with age （ P 〈0 . 05）. The voiding stage symptom （VSS） , storage stage symptom （SSS） and pos tvoid stage symptom （PSS） were positively correlated with age, WHR and SBP （P〈0. 05）. The SSS was positively correlated with DBP （P〈0. 05）. Con-clusions ：MS and its components are the risk factors of BPH, and can promote the development and clinical progression of BPH.