摘要
目的:观察四妙勇安汤合犀黄丸加减联合西药治疗溃疡型胃癌的临床疗效及对患者人异粘蛋白(MTDH)表达的影响。方法:将溃疡型胃癌患者76例随机分为对照组与观察组,各38例。对照组采用常规西药治疗,观察组在对照组的基础上加用四妙勇安汤合犀黄丸加减方治疗,观察患者症状及体征的改善情况,比较2组治疗效果,并检测治疗前后患者MTDH蛋白表达水平。结果:总有效率观察组为89.47%,对照组为63.16%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者胃脘痛、五心烦热、痞满、便干色黑症状积分均较治疗前降低(P<0.05),且观察组上述各项积分下降较对照组更显著(P<0.05)。治疗后MTDH过度表达率观察组为13.16%,对照组为36.84%,2组比较,差异有统计学意义(P<0.05)。2组治疗期间均未见严重不良反应。结论:采用中药四妙勇安汤合犀黄丸加减联合西药常规方案治疗溃疡型胃癌,可提高临床疗效,降低MTDH过度表达,安全性较高。
Objective：To observe the effect of Simiao Yongan tang combined with Xihuang wan for ulcerative type gastric cancer and its expression of metadherin（MTDH） protein.Methods：Divided 76 cases of patients with ulcerative type gastric cancer into the control group and the observation group,38 cases in each group.The control group was given conventional western medicine treatment,while the observation group was treated with Simiao Yongan tang combined with Xihuang wan on the base of treatment of the control group.Observed improvement of patients ＇ symptom and sign.Compared clinical effect in two groups and measured MTDH protein expression level before and after treatment.Results：The total effective rate was 89.47% in the observation group,and was 63.16% in the control group,difference being significant（P〈0.05）.After treatment,scores of epigastric pain,burning sensation of five centres,distention and fullness,dry and black stool in two groups were all decreased（P〈0.05）,and scores mentioned above in the observation group were decreased more obviously than those in the control group（P〈0.05）.After treatment,MTDH over expression rate was 13.16% in the observation group,and was 36.84% in the control group,difference being significant（P〈0.05）.Serious adverse reactions were not found in two groups during treatment.Conclusion：Simiao Yongan tang combined with conventional western medicine for ulcerative type gastric cancer can improve clinical effect,reduce MTDH over expression.Its safety is high.
出处
《新中医》
CAS
2016年第8期215-217,共3页
New Chinese Medicine
