XRCC2基因R188H位点多态性与大肠癌易感性的Meta分析

Association between XRCC2 R188H Polymorphism and Risk of Colorectal Cancer:A Meta-Analysis

目的 通过系统性回顾性分析评价X射线交错互补修复基因2（XRCC2）基因多态性与大肠癌易感性的相关性,以期为大肠癌的临床诊断提供相应参考。方法 计算机检索知网、万方、PubMed,Embase,WebofScience和CNKI数据库,2000年1月-2015年12月XRCC2基因R188H多态性与大肠癌的病例对照研究,应用RevMan5.3及Stata软件进行定量分析。结果 共纳入5篇病例-对照研究：大肠癌病例组2 106例,正常对照组2 607例。Meta分析结果显示,XRCC2 R188H基因多态性与大肠癌发病风险的差异无统计学意义。GA vs GG基因型[OR=1.08,95%CI（0.92-1.27）,P=0.36]。AA vs GG 基因型[OR=1.26,95% CI（0.81-1.97）,P=0.31]。GA＋AA vs GG基因型[OR=1.04,95% CI（0.87-1,23）,P=0.69]。AAvs GG＋GA基因型[OR=1.26,95%CI（0.81-1.96）,P=0.31]。结论 XRCC2 R188H基因多态性与大肠癌易感性无关,而进一步的验证则仍需要更大样本的多中心随机化对照试验进行研究。

Objective To investigate the association between X-ray repair complementing gene 2 （XRCC2） gene polymor- phism and the Colorectal Cancer susceptibility. And to provide the evidence for the diagnosis of the Colorectal Cancer. Methods Related literatures published from January 2000 to December 2015 in the CNKI,Wanfang,PubMed,EMbase and Web of Science were included in this study. RevMan 5.3 and Stata software was used for the quantitative analysis. Results Five case-control studies were included in this study,including 2 106 cases with carcinoma of large intestine and 2 607 control. Meta analysis revealed XRCC2 polymorphism was not associated with the risk of Colorectal Cancer. GAvs GG model[OR： 1.08,95% CI（0.92-1.27）,P=0.36]. AA vs GG model[OR = 1.26, 95 % CI（0. 81-1. 97）, P = 0.31]. GA＋AA vs GG model [OR=1.04,95%CI（0.87-1,23）,P=0.69]. AA vs GG＋GA model [OR=1.26,95% CI（0.81-1.96）,P=0.31]. Conclusion XRCC2 R188H polymorphism was not associated with Colorectal Cancer. And further studies are still needed to confirm the result.