联合检测Ficolin-3,TRF及hs-CRP对2型糖尿病早期诊断价值

Early Diagnostic Value of Combined Detection of Ficolin-3,TRF and hs-CRP for Type 2 Diabetes

目的 探讨联合检测血清纤维凝胶蛋白-3（Ficolin-3）、转铁蛋白（TRF）及超敏C反应蛋白（hs-CRP）对2型糖尿病（T2DM）的早期诊断价值。方法 选取深圳福田人民医院2013年10月-2015年10月收治的T2DM前期患者80例[空腹血糖受损（IFG）35例,糖耐量减低（IGT）45例]为A组,另外选取健康体检人群55例为B组,测定研究对象血清Ficolin-3,TRF及hs-CRP水平,评估其对于T2DM的早期诊断价值。结果 A组患者Ficolin-3,TRF及hs-CRP水平明显高于B组（27.4±2.5 μg/ml vs 18.9±2.3 μg/ml,277±12.7 mg/dl vs 219±9.8 mg/dl,3.68±0.74 mg/ml vs 1.23±0.83 mg/ml）,差异具有统计学意义（P〈0.05）; 单独检测,对早期T2DM诊断的特异度和阳性预测值由高到低依次为TRF〉Ficolin-3〉hs-CRP（63.7%〉54.5%〉36.4%,72.2%〉70.5%〉50.7%）,敏感度和阴性预测值由高到低为Ficolin-3〉TRF〉hs-CRP（70.0%〉65.0%〉45.0%,60.0%〉55.6%〉31.3%）; 以串联方式检测,检测Ficolin-3,TRF及hs-CRP对早期T2DM的诊断特异性显著提高（89.5%）,以并联方式检测,检测Ficolin-3,TRF及hs-CRP对早期T2DM的诊断敏感性显著提高（94.2%）。结论 联合检测血清Ficolin-3,TRF及hs-CRP对T2DM早期诊断具有重要价值,可有效提高早期T2DM诊断的特异度和灵敏度,值得临床推广。

Objective To explore the early diagnostic value of combined detection of Ficolin 3,TRF and hs-CRP for type 2 diabetes （T2DM）. Methods 80 cases of pre-T2DM patients in Shenzhen Futian People＇s Hospital were collected as group A [impaircd fasting glucose （IFG） 35 cases of impaired glucose tolerance （IGT） 45 cases）] from October 2013 to October 2015,55 cases of healthy people were incontrol group B. Serum Ficolin-3,TRF and hs-CRP levels of patients in two were test,evaluate the early diagnostic value of type 2 diabetes （T2DM）. Results The Ficolin 3,TRF and hs-CRP levels of patients in A group wcre significantly higher than those in group B （27.4±2.5 〉g/ml vs 18.9±2.3μg/ml,277±12.7 mg/ dl vs 219±9.8mg/dl,3.68±0. 74 mg/ml vs 1.23±0.83 mg/ml） ,the difference was statistically significant （P〈0.05）. Individually tested, specificity and positive predictive wdue of early diagnosis of T2DM in descending order of TRF〉Ficolin-3 〉hs-CRP （63.7%〉54.5%〉36.4%,72.2%〉70.5%〉50.7%）,the sensitivity and negative predictive value from high to low Ficolin-3〉TRF〉hs-CRP （70.0%〉65.0%〉45.0% ,60.0%〉55.6%〉31.3%）. In series testing,test Ficolin-3, TRF and hs CRP for early diagnosis of T2DM significantly increased significantly （89.5%）,in parallel testing, the sensitivi ty of testing Ficolin-3,TRF and hs CRP for early diagnosis of T2DM improved significantly （94.2%）. Conclusion Combined detection of serum Ficolin-3,TRF and hs-CRP is valuable for the early diagnosis of type 2 diabetes,and can improve the specificity and sensitivity of early diagnosis of T2DM effectively. It should be popularized.