心功能不全透析患者检测纤维蛋白单体的临床意义

Clinical Significance of Detection Fibrin Monomer in Hemodia Lysis with Cardiac Insufficiency Patients

目的 探讨血液透析患者检测纤维蛋白单体的临床意义。方法 血液透析患者按活动性分级为Ⅰ-Ⅱ级22例,Ⅲ-Ⅳ级38例。对不同心功能级的血液透析患者及正常对照组进行血浆凝血酶原时间（PT）,活化的部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（Fg）、D-二聚体（D-dimer）和纤维蛋白单体（FM）定量检测并进行统计学分析。结果 血液透析患者心功能Ⅰ-Ⅱ级组和Ⅲ-Ⅳ级组分别与对照组比较TT,PT,APTT和Fg水平差异无统计学意义（t=0.33-0.58,均P〉0.05）,D-二聚体和FM水平差异有统计学意义（t=6.15-7.45,t=8.41-11.65,均P〈0.05）。心功能Ⅲ-Ⅳ级组D-二聚体水平比心功能Ⅰ-Ⅱ级组高,但两组差异无统计学意义（t=0.38,P〉0.05）。FM水平差异有统计学意义（t=12.35,P〈0.05）。结论 FM是透析患者心功能不全早期诊疗的敏感指标。

Objective To investigate the clinical significance and level changes of Fibrin Monomer on Hemodialysis with cardiac insufficiency patients. Methods According to cardiac function,the Hemodialysis patients were divided into Ⅰ-Ⅱ grade （22 cases）, Ⅲ-Ⅳ grade （38 cases）. They were detected blood coagulation factor （PT, APTT and TT）, fibrinogen （Fg）, D- dimer and Fibrin Monomer（FM）. Results There were no ohvious differences of PT, APTT,TT and Fg levels hetween patients and normal group （t=0.33-0.58,P〉0.05） ,and obvious differences of D-dimer and FM （t=6.15-7.45,t=8.41- 11.65, P〈0.05）. The level of D-DI between cardiac insufficiency patients of Ⅰ-Ⅱ stage and Ⅲ-Ⅳ stage were no differences （t=0.38,P〉0.05）. The complicated with cardiac insufficiency group of Ⅲ-Ⅳ stage had a higher FM levels than those of Ⅰ-Ⅱ stage（t=12.35,P〈0.05）. Conclusion Detection of FM could he a more sensitive marker for diagnosing and treatment to Hemodialysis patients with cardiac insufficiency.