尿微量白蛋白阴性2型糖尿病患者血清肿瘤坏死因子受体水平与肾功能损害程度相关性分析excretion

Correlation of serum TNFR level with renal function injury in patients with T2DM and normal albumin ;excretion

目的：探讨尿微量白蛋白阴性2型糖尿病（T2DM）患者肿瘤坏死因子受体1（TNFR1）、TNFR2含量与肾功能损害程度的关系。方法将90例尿微量白蛋白阴性（24 h 尿白蛋白排泄率＜20μg／min）T2DM患者按肾小球滤过率（eGFR）水平分为三组，eGFR ＞90 mL·min －1·（1．72 m2）－1、eGFR 60-90 mL·min －1· （1．72 m2）－1和 eGFR ＜60 mL·min －1·（1．72 m2）－1各30例，测定血清 TNFR1、TNFR2水平，同时记录相关临床指标，进行统计学分析。结果尿微量白蛋白阴性 T2DM患者血清 TNFR1、TNFR2水平与 eGFR 呈负相关关系（r ＝－0.428、－0．335，均 P ＜0．05），与血肌酐（Scr）呈正相关（r ＝0．476、0．225，均 P ＜0．05）。同时病程、尿素氮（BUN）、Scr、血清胱抑素 C（CysC）、α1微球蛋白（α1-MG）、β2微球蛋白（β2-MG）随肾功能损害程度加重而升高，各组间差异均有统计学意义（F ＝3．758、5．851、71.738、25．751、7．530、13．735，均 P ＜0．05）。Logistic 回归分析显示，TNFRs 是尿微量白蛋白阴性 T2DM患者肾功能损伤的独立危险因素（OR ＝2．009、1.143，均 P ＜0.05）。结论TNFRs 可能参与尿微量白蛋白阴性 T2DM患者肾损伤的发生、发展，可在一定程度上反映这些患者的肾功能损伤程度，或可作为一项常规监测糖尿病肾损伤的指标。

Objective To discuss the correlation of serum TNFR level with renal function injury in patients with type 2 diabetes mellitus （T2DM）and normal albumin excretion.Methods 90 T2DMpatients with normal albu-min excretion（24h urine albumin excretion rate 〈20μg/min）were divided into three groups according to the esti-mated glomerular filtration rate level：eGFR 〉90mL · min -1 · （1.72m2 ）-1 ,eGFR 60 -90mL · min -1 · （1.72m2 ）-1 and eGFR 〈60mL·min -1 ·（1.72m2 ）-1 ,30 cases in each group.The serum TNFRs level and related clinical data were measured and analyzed statistically.Results The levels of serum TNFR1,TNFR2 were negatively correlated with eGFR（r =-0.428,-0.335,all P 〈0.05）,and positively correlated with Scr（r =0.476,0.225,all P 〈0.05）in patients with T2DM and normal albumin excretion.The course of disease and the levels of BUN,Scr, CysC,α1 -MG,β2 -MG were increased as the degree of renal function injury.All these index had statistically signifi-cant differences in three groups（F =3.758,5.851,71.738,25.751,7.530,13.735,all P 〈0.05）.Logistic regres-sion analysis showed that the levels of serum TNFR1,TNFR2 were independent risk factors for renal impairment in patients with T2DMand normal albumin excretion（OR =2.009,1.143,all P 〈0.05）.Conclusion TNFRs may be involved in the development and progression of renal impairment,and may become a new conventional indicator for DN because of reflecting the degree of renal function injury in some extent in T2DMpatients with normal albumin excretion.