期刊文献+

癌胚抗原相关黏附分子6在胃腺癌患者中的表达 被引量:3

下载PDF
导出
摘要 目的:探讨癌胚抗原相关黏附分子-6(CEACAM-6)在胃腺癌患者中的表达,为癌症的早期诊断与评估治疗提供依据。方法:将56例胃腺癌根治手术患者作为观察组,58例正常胃黏膜组织作为对照组。对两组CEACAM-6应用免疫组化方法进行阳性检测。结果:观察组CEACAM-6阳性率为44.64%明显高于对照组(P<0.05);观察组中不同年龄、性别与肿瘤大小中CEACAM-6阳性率表达比较无显著性差异(P>0.05);分化程度程度低的患者CEACAM-6阳性率明显高于分化程度高、中的患者(P<0.05);有淋巴转移的患者CEACAM-6阳性率明显高于无淋巴转移的患者(P<0.05);Logistics分析结果显示:分化程度越低,有淋巴转移患者的CEACAM-6阳性表达率越高(P<0.05)。结论:胃腺癌术后组织中CEACAM-6表达明显高于正常胃组织,且在分化程度低和有淋巴转移的患者中更高。
出处 《陕西医学杂志》 CAS 2016年第9期1262-1263,共2页 Shaanxi Medical Journal
  • 相关文献

参考文献1

二级参考文献27

  • 1Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61: 69-90.
  • 2Zhao ZS, Li L, Wang HJ and Wang YY. Expression and prognostic significance of CEACAM6, !TGB I, and CYR61 in peripheral blood of patients with gastric cancer. J Surg Onco12011, 104: 525-529.
  • 3Beauchemin N and Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev 2013, 32: 643-671.
  • 4Scholzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B and Thompson J. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Patho12000, 156: 595-605.
  • 5Czepczynska-Krezel H and Krop-Watorek A. [Human carcinoembryonic antygen family proteins, structure and function]. Postepy Hig Med Dosw (Online) 2012, 66: 521-533.
  • 6Panczyszyn A and Wieczorek M. [Role of CEACAM in neutrophil activation]. Postepy Hig Med Dosw (Online) 2012, 66: 574-582.
  • 7Chapin C, Bailey NA, Gonzales LW, Lee JW, Gonzalez RF and Ballard PL. Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lung. Am J Physiol Lung Cell Mol Physiol2012, 302: 216-225.
  • 8Kim KS, Kim JT, Lee SJ, Kang MA, Choe IS, Kang YH and Kim SY, et al. Overexpression and clinical significance of carcinoembryonic antigenrelated cell adhesion molecule 6 in colorectal cancer. Clin Chim Acta 2013, 415: 12-19.
  • 9JantscheffP, Terracciano L, Lowy A, Glatz-Krieger K, Grunert F, Micheel B and Brummer J, et al. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol 2003, 21: 3638-3646.
  • 10Duxbury MS, Matros E, Clancy T, Bailey G, Doff M, Zinner MJ and Ashley SW, et al. CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. Ann Surg 2005, 241: 491-496.

共引文献4

同被引文献40

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部