丽水市2型糖尿病患者维生素D水平及相关因素分析

An analysis on the relationship between vitamin D levels and related factors among type 2 diabetic patients in Lishui City

目的分析2型糖尿病(T2DM)患者维生素D水平及相关影响因素,为干预性研究提供依据。方法采用分层随机抽样方法抽取丽水市10个街道/乡镇270例T2DM患者,开展问卷调查、体格检查及实验室检测。采用高效液相色谱-串联质谱法检测血清25(OH)D3水平,并分析其相关影响因素。结果 270例T2DM患者血清25(OH)D3平均为(22.97±8.07)ng/m L;男性患者25(OH)D3中位数为25 ng/m L,高于女性患者的21 ng/m L(P<0.05);农村患者为23 ng/m L,高于城市患者的20 ng/m L(P<0.05);超重及肥胖的T2DM患者低于BMI正常者(P<0.05)。多元线性回归分析显示,性别、城乡户籍和户外活动时间是维生素D水平的影响因素,β值分别为-5.178、2.369和2.026(P均<0.05)。结论 T2DM患者维生素D水平与性别、城乡户籍、户外活动时间相关,应加强对T2DM患者的维生素D水平监测与户外活动干预。

Objective To analyze serum vitamin D level in patients with type 2 diabetes mellitus（T2DM） ,and to provide evidence for the intervention. Methods A total of 270 blood samples from patients with T2DM by multi - stage random sampling in 10 streets/towns in Lishui City were collected to test 25 - hydroxyvitamin D level by high performance liquid chromatography - tandem mass spectrometry. Results The average level of 270 case of T2DM patients 25 - hydroxyvitamin D was （ 22. 97 ± 8. 07） ng/mL. Gender, household registration, BMI stage and 25 - hydroxyvitamin D level were statistically significant, respectively （ Z = 4. 13 , P 〈 0. 05） , （Z = 2. 44, P 〈0. 05） , （ F = 3. 21 〈0. 05） . Bymultiple linear regression analysis, we found that gender, household registration and length of outdoor exercise time was related to vitamin D level, the B value were - 5. 178 , 2. 369, and 2. 026, respectively （ P 〈 0. 05 ） . Conclusion T2DM patients had lower level vitamin D in their blood. Vitamin D had negative correlation with gender, household registration, and outdoor exercise time. T2DM patients ’ vitamin D monitoring and outdoor activities should be strengthened.