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HBV基因组C基因分子生物学的研究进展

Advances in Molecular Biology of C Gene of Hepatitis B Virus
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摘要 乙型肝炎病毒(HBV)C基因包含前C区基因和C区基因,分别编码乙型肝炎e抗原(HBeAg)和乙型肝炎核心抗原(HBcAg)。HBeAg参与免疫调节,并且是乙型肝炎传染性的标志之一。HBcAg是核衣壳的组成蛋白,在病毒颗粒的组装、成熟、诱导免疫反应以及致肝病、肝癌的分子机制中起着重要的作用。文章就HBV基因组C基因分子生物学的研究进展作一综述。 Hepatitis B virus（HBV）core gene contains preC and C region,coding HBV e antigen（HBeAg）and HBV core antigen（HBcAg）,respectively.HBeAg is involved in immune regulation and used as a sign of HBV infection.HBcAg is an important component of nucleocapsid.It plays a critical role in the assembly and maturation of HBV virion,induction of immune response, and pathogenesis of liver diseases and hepatocarcinoma.This paper reviews the research progress in molecular biology of HBV genomic C gene.
作者 夏方娜 刘金辉
机构地区 南昌大学基础医学院微生物学教研室
出处 《南昌大学学报（医学版）》 CAS 2016年第4期83-86,94,共5页 Journal of Nanchang University：Medical Sciences
基金 江西省教育厅科技基金资助项目(GJJ12069)
关键词 乙型肝炎病毒基因组C基因 乙型肝炎E抗原 乙型肝炎核心抗原 核衣壳 hepatitis B virus genomic C gene hepatitis B virus e antigen hepatitis B virus core antigen cleocapsid
分类号 R37 [医药卫生—病原生物学] R392 [医药卫生—免疫学]
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南昌大学学报（医学版）
2016年 第4期

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