结直肠腺癌血管生成拟态的形态学观察及其临床病理意义

Morphology of vasculogenic mimicry in colorectal adenocarcinoma and its clinicopathologic significance

目的:研究结直肠腺癌中是否存在血管生成拟态(vasculogenic mimicry,VM)及其临床病理意义。方法:收集156例结直肠腺癌组织学标本及其临床资料,利用CD34和PAS双重染色,观察是否存在VM,分析VM的形成与结直肠腺癌临床病理指标的关系。结果:156例结直肠腺癌中有31例存在VM,阳性率为19.87%,VM的形成与肿瘤大小无关,在低分化组、伴有血管及神经侵犯组、伴有淋巴结转移组,VM的阳性率比在中分化和高分化组、无血管及神经侵犯组、无淋巴结转移组高,差异有统计学意义(P<0.05)。结论:结直肠腺癌中存在VM,VM形成与结直肠腺癌的侵袭性或远处转移相关。

Objective：To study whether vasculogenic mimicry（ VM） exists in colorectal adenocarcinoma and its clinicopathologic significance. Methods： A total of 156 cases of colorectal adenocarcinoma was collected and dual stai-ning of CD34 and periodic acid -Schiff（PAS） were performed to validate the existence of VM in colorectal adenocar-cinoma. Then the correlation between VM and clinical pathologic factors of colorectal adenocarcinoma was studied. Re-sults ： Of 156 colorectal adenocarcinoma cases, VM existed in 31 cases （ 19. 87 % ） . It was significantly correlated with poor differentiation, nerval and vessel invasion, and lymph node metastasis （ P 〈0.05）. Conclusion： VM exists in colorectal adenocarcinoma, maybe it associated with invasion and Metastasis of colorectal adenocarcinoma.