宫颈癌患者血清1,25-(OH)_2D_3水平检测及临床意义

Clinical significance of serum level of 1,25-(OH)_2D_3 in patients with cervical cancer

目的:检测不同宫颈病变患者血清中1,25-(OH)_2D_3的水平,初步探讨1,25-(OH)_2D_3与宫颈癌临床特征的相关性。方法:对2014年7月至2015年7月收治的116例宫颈病变患者,采用放射免疫法检测血清中1,25-(OH)_2D_3水平,并以40例健康体检者血清作对照。结果:宫颈癌及宫颈良性病变患者血清1,25-(OH)_2D_3水平均低于健康对照组,差异有统计学意义(P<0.05),宫颈癌与子宫良性病变组之间无显著性差异(P>0.05)。宫颈癌组中,绝经前患者血清中1,25-(OH)_2D_3水平高于绝经后患者血清水平(P<0.05),宫颈癌组织分级越差,淋巴结越多,FIGO分期越晚,血清中1,25-(OH)_2D_3水平明显降低。结论:血清中1,25-(OH)_2D_3水平降低可能与宫颈癌进展有关。

Objective： To detect the serum level of 1 , 25 - （OH） 2D3 of patients w ith different cervical lesions, and to explore the correlation between 1,25 - （OH）2D3 and clinical features of cervical cancer. Methods： All 116 cases of cervical lesions were treated from July 2014 to July 2015. The serum levels of 1,25 - （ OH）2D3 were detected by radioimmunoassay, and 40 cases of healthy persons were used as control. Results ： The serum level of 1 ,2 5 - （OH） 2 D3 in cervical cancer and benign lesions patients was lower than that of the healthy control group, and the difference was statistically significant （P 〈0.05） ,however,between cervical cancer and benign lesion groups was no significant difference （P 〉 0. 05 ） . In cervical cancer patients , premenopausal serum 1,25 - （ OH） 2 D3 was higher than postmenopausal patients serum levels （P〈0.05） ,and worse classification of cervical carcinoma, lymph node more, FIGO stage in the later, serum 1,25 - （OH）2D3 decreased significantly. Conclusion： The decrease of 1 ,2 5 - （OH）2D3 level in serum may be related to the progression of cervical cancer.