摘要
胃癌是严重危害人类健康的消化系统恶性肿瘤,发病率一直居高不下。胃动蛋白(gastrokines,GKNs)是人体胃部产生的可抑制胃癌细胞生长的蛋白,其在正常组织中大量表达,在胃癌及其癌前病变中表达下调或缺失,在抑制胃癌增殖过程中发挥重要作用,并且与胃癌有关的其他因素如幽门螺杆菌感染、三叶因子等存在复杂联系。本文对GKNs抑制胃癌细胞增殖的研究进展进行文献总结。
Gastric cancer is seriously dangerous to human health with constantly high incidence. Human gastric mucosa can express gastrokines that can inhibit cancer cell growth. Gastrokines is expressed abundantly in normal tissues while downregulated or absent in gastric cancer and precancerous lesion. It plays an important role in the suppression of gastric cancer proliferation combining with the other factors such as helicobacter pylori infection or trefoil factors. In this paper we made a review about the suppression of gastrokines on gastric cancer cell proliferation.
出处
《中国微创外科杂志》
CSCD
北大核心
2016年第9期852-854,共3页
Chinese Journal of Minimally Invasive Surgery
基金
国家自然科学基金(项目编号:30770980
81270475)
