HSP70基因多态性在维吾尔族和汉族煤工尘肺患者分布的差异性分析

Analysis on the differences of HSP70 gene polymorphism between uygur and han coal workers with pneumoconiosis

目的阐明新疆汉族和维吾尔族煤工尘肺患者中热休克蛋白70(heat shock protein 70,HSP70)基因多态性分布及差异性分析。方法随机选取2014年3月-2014年12月在新疆维吾尔自治区职业病医院接受治疗的煤工尘肺患者共275人,其中汉族煤工尘肺患者156人,维吾尔族煤工尘肺患者119人。采用Taqman基因分型方法检测两组人群中HSP70三位点基因型和等位基因分布情况。结果在汉族与维吾尔族尘肺患者之间HSP70-1+190(G/C)、HSP70-2+1267(A/G)和HSP70-hom+2437(T/C)三位点基因型及等位基因的分布均无统计学差异(P>0.5)。结论汉族与维吾尔族尘肺患者之间HSP70-1+190、HSP70-2+1267和HSP70-hom+2437三位点基因型及等位基因分布均差异无显著性。

Objective To illustrate gene polymorphism and its difference on heat shock protein 70（HSP70） among uygurs and han coal workers with pneumoconiosis in Xinjiang.Methods 275 patients with pneumoconiosis in the Occupational Disease Hospital of the Xinjiang Uygur Autonomous Region from March 2014 to December 2014 were randomly selected,including 156 han nationalities and 119 Uygur coal workers.Taq Man genotyping methods was used to detect HSP70 genotype distribution between two groups.Results Distribution of HSP70-1 ＋ 190（G/C）,HSP70-2 ＋ 1267（A/G） and HSP70-hom ＋ 2437（T/C） loci genotype and allele had no statistical difference between han nationality and uygurs patients（P〈0.5）.Conclusion Distribution of HSP70-1＋190,HSP70-2＋1267 and HSP70-hom ＋ 2437 loci genotype and allele have no statistical difference between han nationality and uygurs patients pneumoconiosis.