北京市区居民糖化血红蛋白的冬夏季变化

Winter and summer seasonal variation of glycosytated hemoglobin Ale in Beijing residents

目的观察北京市区居民糖化血红蛋白（HbA1c）的冬夏季变化。方法选取2013年1月至2015年12月于北京医院就诊和体检的北京地区无糖尿病及有糖尿病2年以上且病情稳定者共2438人为研究对象，观察其冬（12月至次年3月）夏（7月至10月）季HbA1c配对结果。一人多次检测的只保留2月（代表冬季）和9月（代表夏季）的结果。分别按冬夏季HbA1c水平、年龄进行分组，比较不同HbA1c水平冬夏季差别及不同年龄段的HbA1c冬夏季差别。冬夏季HbA1c水平用配对t检验进行统计分析。结果全体观察对象存在HbA1c冬季高、夏季低的统计学差别[（6．8±1．3）％比（6．6±1．1）％，t=11．45，P〈0．01]。HbA1c〈5．7％、5．7％～6．4％及≥6．5％者均存在HbA1c冬季高、夏季低的结果（t=2．48、8．44、9．96，均P〈0．05）。各组均有HbA1c冬季高、夏季低的统计学差别（t=2．26～7．01）。对2438例中的312例进行了连续冬夏季2年的观察，结果也存在HbA1c冬季高、夏季低的统计学差异（t=3．11～3．16，均P〈0．05）。结论北京地区存在HbA1c冬季高、夏季低的差别，且这种差别与HbA1c水平高低、性别及年龄无关。

Objective To observe the winter and summer seasonal variation of hemoglobin A1c（HbA1c）in Beijing residents. Methods Two thousand four hundred thirty-eight subjects who visiting Beijing Hospital from 2013 to 2015 were enrolled, including normal glycemia persons and diabetes mellitus patients whose blood glucose was controlled stable during last 2 years. HbA1c values were measured both in winter （December-March） and in summer （July-October） to compare in paired method. The result of HbA1c, in February and September is considered as winter and summer respectively, when repeat test was done for the same person. The data was grouped by season and age to compare the difference of HbA1c values in different season and different age. The HbA1c, values in different seasons were analyzed with paired-sample t test. Results HbA1c was higher in winter than that in summer independent of gender（6.8±1.3）% vs （6.6± 1.1）%, t=11.45, P〈0.01）. The seasonal variation of HbA1c could be observed in different HbA1c, levels, including HbA1c〈5.7%, 5.7%-6.4% and≥6.5% （t=2.48,8.44,9.96, respectively, all P〈0.05）. In different age groups, age≤30, 31-40, 41-50, 51-60, 61-70, 71-80, 〉80 yrs, respectively, we also found HbA1c, values were higher in winter than that in summer （t=2.26-7.01, P〈0.05）. 312 subjects had a 2-year consecutive observation of HbAjo both in summer and in winter. The HbA1c values in winter were also higher than that in summer statistically（t=3.11-3.16, all P〈0.05）. Conclusions In Beijing residents, HbA1c values are higher in winter than that in summer, independently of HbA1c level, age and gender.