消渴丸联合甘精胰岛素对新诊2型糖尿病临床疗效观察

Clinical Efficacy Observation of Xiaoke Pill Combined with Glargine in Newly Diagnosed Type 2 Diabetes Patients

目的:观察消渴丸联合甘精胰岛素对新诊2型糖尿病患者(糖化血红蛋白>9.0%)的临床疗效。方法:将60例初诊2型糖尿病患者随机分为治疗组(A组,30例)与对照组(B组,30例),两组患者在控制饮食与运动的的基础上,于3餐前30min,A组患者予口服消渴丸,B组患者给予格列本脲,两组患者同时每晚固定时间注射甘精胰岛素,治疗12周,观察治疗前后两组患者血糖(空腹血糖、餐后2h血糖)、糖化血红蛋白、BMI及低血糖发生情况。结果:两组患者治疗后的空腹血糖(FPG)、餐后2h血糖(2hPG)、HbAlc较治疗前均显著下降(P<0.05);且治疗组较对照组下降更明显(P<0.05)。两组患者BMI指数治疗前后无显著性差异(P>0.05);且均无低血糖发生。结论:消渴丸联合甘精胰岛素治疗能有效降低新诊2型糖尿病患者的血糖,且对病人体重影响小,有安全、方便、依从性高的特点,值得临床推广应用。

Objective：To observe the effect of Xiaoke pill combined with Gan clinical efficacy of newly diagnosed type 2 diabetic patients （glycated hemoglobin 〉9.0 %） insulin glarglne. Methods： Will 60 cases of newly diagnosed type 2 diabetic patients were randomly divided into the treatment group （group A, 30 cases） and control group （group B,n=30）, the patients in the two groups in the control diet and exercise based, on 3 meal front 30rain. Patients in group A were given Xiaoke pill. Patients in group B received glibenclamide, two groups of patients at the same time every night time fixed injection Oan insulin glargine, 12 weeks of treatment, observed be/ore and after treatment in two groups patients blood glucose （fasting blood glucose, postprandial 2H blood glucose, HbAlc, BMI, hypoglycemia incidence. Results： Two groups of patients after treatment of fasting blood glucose （FPG）, postprandial 2h blood glucose （2hPG）, HbAlc than before treatment were significantly decreased （P〈0.05）, and the treatment group than the control group decreased significantly （P〈0.05）. There was no significant difference between the two groups before and after BMI index （P〉0.05）, and there was no occurrence of hypoglycemia. Conclusion：Xiaoke pill combined with Gan insulin glargine therapy can effectively reduce the newly diagnosed type 2 diabetic patients blood glucose, and small impact on the patient＇s weight, safe, convenient, high compliance, it is worth of clinical application.