柴胡疏肝散对原发性抑郁症患者BAEP、VEP的影响

Effect of Chaihu Shugan Powder on BAEP and VEP of Patients with Primary Depression

目的:观察柴胡疏肝散对原发性抑郁症患者脑干听觉诱发电位(BAEP)和视觉诱发电位(VEP)的影响。方法:将100例原发性抑郁症患者随机分为中药组、西药组,分别给予中药柴胡疏肝散和盐酸帕罗西汀治疗,采用脑诱发电位仪,记录治疗前后BAEP和VEP。结果:两组经治疗后,BAEP的I、V波治疗前后无明显改变(P>0.05),Ⅲ波潜伏期较治疗前明显缩短(P<0.05),VEP各波潜伏期均显著缩短(P<0.05);治疗后两组BAEP、VEP相比无统计学差异(P>0.05)。结论:柴胡疏肝散可缩短原发性抑郁症患者BAEP和VEP的潜伏期,减轻患者临床症状,具有应用价值。

Objective： To observe effect of Chaihu Shugan Powder on brain stem auditory evoked potentials and visual evoked potentials of patients with primary depression. Methods： A total of 100 cases of depression patients were randomly divided into traditional Chinese medicine group and Western medicine group,which were given Chaihu Shugan Powder and paroxetine hydrochloride treatment respectively. We documented the brain stem auditory evoked potential（ BAEP） and visual evoked potential（ VEP）. Results： After treatment,I and V waves of two groups had no obvious change（ P 〉 0. 05）. The latent period of wave BAEPⅢ was significantly shortened（ P 〈 0. 05） and the latent period of the VEP significantly shortened（ P 〈 0. 05）. After treatment,traditional Chinese medicine group’s BAEP compared with that of the Western medicine group had no statistical difference（ P 〉0. 05）. Conclusion： Chaihu Shugan Powder markedly shorten the latent period of brain evoked potentials to the patients with primary depression,improving patients’ clinical symptoms.