吸入薰衣草精油对原发性失眠症患者的临床疗效

Clinical effect of insomnia patients by inhalation lavender essential oil

目的观察吸入不同浓度薰衣草精油对原发性失眠症患者的疗效。方法从2013年1月～2015年1月安徽医科大学第四附属医院神经内科住院患者中选取受试者，随机分为5组，分为100％、1％、1％。薰衣草精油组。葡萄籽油组，空白组，前4组睡前吸入上述物质，每天10min，连续一周，空白组不做任何处理，多导睡眠监测（PSG）结果探讨其对失眠的疗效和筛选出适宜浓度。结果吸入薰衣草精油一周后，PSG结果显示其可缩短睡眠潜伏期、延长睡眠时间、提高睡眠效率及睡眠维持率、增加（S3＋S4）及非快速动眼睡眠百分比，降低血压。其中l％浓度薰衣草精油组与空白组比较差异有统计学意义（P〈0．05），吸入葡萄籽油上述指标无明显变化。与空白组比较差异无统计学意义（P〉0．05）。实验过程中无明显不良反应。结论嗅觉途径吸入薰衣草精油可安全而有效地改善原发性失眠症患者的失眠情况，其中1％浓度的效果更佳，葡萄籽油无改善睡眠作用。

Objective To discuss the clinical effect of insomnia patients in hospital by inhalation different concentra- tions of lavender essential oil. Methods Subjects were chosen from hospitalized patients in the Fourth Affiliated Hospital of Anhui Medical University from January 2013 to January 2015. They were randomly divided into five groups, namely 100%, 1%, 1‰ lavender essential oil groups and grape seed oil group and control group. The top four groups inhaled above subjects for 10 minutes per day for one week before sleeping. Control group did not be disposed. Its clinic effect and the suitable concentration by the results of Polysomnography （PSG） were discussed. Results Inhalation of lavender essential oil for one week, PSG showed that it could cut sleep latency, extend hours of sleep, increase the sleep efficiency and sleep maintenance rate, increase percentage of （S3＋S4） and NREM of subjects, lower blood pressure. Compared to the control group, the 1% lavender essential oil group had a statically significance （P 〈 0.05）. The above observation items of grape seed oil had no obvious changing. Compared to control group, there was no statically significance （P 〉 0.05）. Conclusion Inhalation different concentration of lavender essential oil improves the insomnia patients in hospital safely and effectively through olfactory pathway. The 1% concentration has the better effect. The grape seed oil has no effect on improving insomnia.