72株脑膜败血伊丽莎白菌的临床分布与耐药状况分析

Clinical distribution and drug resistance analysis of 72 strains of Elizabethkingia meningosepticum

目的调查72株脑膜败血伊丽莎白菌的临床分布及耐药现状,为临床合理应用抗菌药物和预防医院感染提供依据。方法采用Phoenix 100型全自动微生物分析系统对临床分离菌株进行菌种鉴定和药物敏感试验,应用WHONET 5.6软件对数据进行统计分析。结果 72株脑膜败血伊丽莎白菌主要分离自痰液标本(占91.6%),从监护病房分离到57株,占79.1%。药敏结果显示,对米诺环素的耐药率为0,其次为复方新诺明(11.8%)和哌拉西林/他唑巴坦(23.5%)。结论脑膜败血伊丽莎白菌除对米诺环素敏感,复方新诺明和哌拉西林/他唑巴坦较敏感外,对常用抗菌药物表现为严重耐药和多重耐药,应加强监测并根据药敏结果合理选用抗菌药物。

Objective To investigate the clinical distribution and drug resistance of 72 strains of Elizabethkingia meningo- septicum so as to provide evidence for clinical rational use of drugs and to prevent hospital infection. Methods The strains of Elizabethkingia meningosepticum isolated from clinical specimens were identified and tested on drug sensitive applied the Phoenix 100 system, and the data was analyzed by WHONET 5.6. Results The 72 strains of Elizabethkingia meningosepti- cum were most isolated from sputum samples（91.6% ）, and 57 of 72 strains were isolated from ICU that accounted for 79.1%. The result showed that Minocycline had the lowest rate （ 0 ） , followed by Trimethoprim - Sulfamethoxazole （ 11.8 % ） and Piperacillin - tazobactam （23.5 % ）. Conclusion Elizabethkingia meningosepticum was seriously resistant and multi - resistant to normal antimicrobial agent. So clinical department should pay more attention to the status, and ra- tionally choose antibiotics according to the drug susceptibility.