多维评分系统评价沙丁胺醇联合布地奈德治疗重度COPD的疗效

Clinical efficacy evaluation of salbutamol combined with budesonide on severe chronic obstructive pulmonary disease by BODE index

目的：比较沙丁胺醇联合布地奈德对慢性阻塞性肺疾病（ COPD）急性加重期患者治疗前后BODE指数的变化，探讨沙丁胺醇联合布地奈德对COPD的临床疗效。方法选取重度COPD患者94例，随机分为试验组（n＝47）和对照组（n＝47），对照组采用沙丁胺醇治疗，试验组在此基础上加用布地奈德。比较两组患者治疗前后的BODE得分。结果治疗后试验组患者1 s用力呼气容积占预计值百分比（ FEV1％ Pred）、呼吸困难程度、6 min步行距离（6MWD）与对照组比较差异有统计学意义（P﹤0.05）；但两组患者治疗前后体质量指数无明显变化，差异未见统计学意义（P﹥0.05）。结论布地奈德联合沙丁胺醇可以有效改善重度COPD患者的BODE指数，疗效肯定。

Objective To investigate the effect of salbutamol combined with budesonide on se-vere chronic obstructive pulmonary disease（ COPD）patients by comparing the BODE index before and after treatment. Methods Ninety-four patients with severe COPD were selected,they were randomly di-vided into experimental group and control group,with 47 cases in each group. Patients in control group were treated with salbutamol,patients in experimental group were treated with salbutamol and budes-onide. The BODE index between the two groups before and after treatment were compared. Results The general information of the two groups had no significant difference before treatment（ P ﹥0 . 05 ）. After treatment,the BODE index,including FEV1% Pred,degree of dyspnoea and 6 MWD in experimental group got better than those in control group,the differences were significant（P﹤0. 05）. The BMI of the experimental group had not changed obviously compared with control group （ P﹥0 . 05 ）. Conclusions Salbutamol combined with budesonide could effectively improved the BODE index of severe COPD.