斑秃发病机制的研究进展

Updates on the Pathogenesis of Alopecia Areata

斑秃（alopecia areata,AA）是一种常见的非瘢痕性脱发性疾病,发病率约为1%-2%。AA的发病机理尚未完全明确,目前普遍认为这是一种因毛囊免疫豁免机制被破坏而引发的器官特异性的、T细胞介导的自身免疫病。在AA的发病中还涉及了多种遗传因素和环境因素的共同作用。文中综述概括了AA发病机制的研究进展。

Alopecia areata（ AA） is a common non-scarring hair loss disorder,which affects approximately 1% - 2% of the general population. The etiopathogenesis of AA remains poorly understood. AA is generally considered to be an organ-specific T-cell-mediated autoimmune disease with loss of the immune privilege of the hair follicles. Multiple genetic factors and environmental factors are involved in the pathology of AA. This review presents a comprehensive study of newer theories in pathogenesis of AA.