白发症与系统疾病

Canities in Internal Disease

白发症(canities)或灰发症(poliosis)是指部分毛发或全部毛发变白或变灰白。是由于各种原因造成毛囊中的黑素细胞产生色素减少,或黑素细胞数量减少甚至缺乏。白发症的病因涉及年龄、遗传、代谢、免疫、内分泌、肿瘤、营养缺乏、及药物等因素。白发症可以是独立的一种疾病,也可以是系统疾病的主要表现之一,有时可作为内脏疾病的重要诊断线索。文中复习文献并对系统疾病伴白发症进行了综述。

Canities is defined as hair discoloration from color hair to white /gray hair in the all the hair or the part,due to various causes resulting in the reduction of hair follicle melanin pigment and melanocytes number or total lack of them. Its etiology is related to age,genetic,metabolic,immune,endocrine,tumor,lack of nutrition,and drug factors. Canities is a localized scalp lesion and also is one of the main manifestations of the internal diseases. So Canities could be important diagnostic clues for general internal diseases such as piebaldism,Waardenburg syndrome,Vogt-Koyanagi-Harada Disease and so on. This article focused on system diseases with canities was reviewed.