25例隐源性机化性肺炎临床分析

Clinical Analysis of 25 Cases of Cryptogenic Organizing Pneumonia

目的:分析经病理确诊为隐源性机化性肺炎(COP)患者的临床特点与影像学特征,以提高临床医生对该病的认识,减少该病误诊。方法:收集经肺活检病理检查证实的25例COP患者的一般资料、临床表现、常规实验室检查及影像学特征,并对这些资料进行综合分析。结果:25例患者中,男15例,女10例,平均年龄(61.4±13.1)岁,吸烟仅占24.0%。所有患者均没有明显的过敏粉尘及工业粉尘相关接触史。临床症状以咳嗽、咳痰(量少)为主要表现,缺乏特征性,实验室检查以白细胞水平正常及血沉增快最常见。胸部CT主要表现为占位性肿块、斑片状及实变影。结论:COP的临床表现及实验室检查缺乏特征性,胸部CT表现主要与肿瘤及肺部感染类似,确诊依靠病理学检查。

Objective：To analyze clinical features and imaging characteristics of cryptogenic organizing pneumonia （COP） confirmed by pathological examination, and improve clinicians understanding of the disease and reduce the disease misdiagnosis. Methods：General information, clinical manifestations,laboratory examination and radiographic features of 25 patients with COP confirmed by pathological examination of lung biopsy were collected, and a comprehensive analysis of these data was made. Results：There were 15 males and 10 females in 25 patients.The mean age was （61.4±13.1） years.And 6 cases （24？？0%） had smoking history. All patients had no obvious allergic and industrial dust related exposure history. The clinical presentations were nonspecific, and the main clinical symptoms were cough with a small amount of sputum. The most common laboratory tests was counting normal white blood cells and faster blood sedimentation.The main features of chest CT were space occupying lesions and patchy consolidation or ground-glass opacification.Conclusion：The clinical manifestation and laboratory examination of COP lack of characteristic, and the chest CT performance is similar to tumor and lung infection, and the diagnosis of COP depends on pathological examination.In order to reduce misdiagnosis,clinical doctors should improve the awareness and vigilance of the disease.