脱氢表雄酮与慢性荨麻疹发病的相关性研究

Correlation between dehydroepiandrosterone and occurrence of chronic urticaria

慢性荨麻疹是皮肤科常见的疾病，其病因和发病机制复杂，大约80％患者找不到明确的病因，临床上存在病情复杂、易反复、抗组胺药物疗效欠佳等诸多问题，严重影响患者的生活质量。近年来，神经内分泌一免疫系统功能障碍受到越来越多的关注，研究发现，其可能是慢性荨麻疹发病机制的一个重要方面。脱氢表雄酮及其硫酸盐衍生物是由神经系统调节分泌，参与神经一免疫调节过程，可能具有调节免疫稳态作用的物质。已有研究指出：慢性荨麻疹患者体内脱氢表雄酮及其硫酸盐衍生物血清浓度大幅下降。然而，脱氢表雄酮及其硫酸盐衍生物循环浓度下降是一个主要原因还仅仅是一个伴随现象，以及其在慢性荨麻疹发病中的意义尚不清楚。

Chronic urticaria （CU） is a common skin disease with complex etiology and pathogenesis, and its cause is unclear in about 80% of patients. In clinic, there are many problems with CU, such as complicated condition, frequent recurrence, poor therapeutic effect of antihistamines, and so on, which seriously affect life quality of patients. In recent years, neuroendocrine-immune system dysfunction has got more and more attention, and has been suggested to play an important role in the pathogenesis of CU. Dehydroepiandrosterone （DHEA） and its sulfate derivative （DHEA-S）, which are secreted and regulated by the nervous system, participate in the process of neuroimmune regulation, and are regarded as potential factors regulating immune homeostasis. It has been reported that serum levels of DHEA and DHEA-S markedly decrease in patients with CU. It is unclear whether the decrease of DHEA and DHEA-S circulation concentrations is a primary cause or just a concomitant symptom of CU, and what role it plays in the development of CU.