疏水改性海藻酸钠衍生物包埋丁香油的释放性

Release of Clove Oil Embedded by Hydrophobically Modified Sodium Alginate Derivative

目的通过化学方法将月桂醇与海藻酸钠接枝共聚形成两亲共聚物,对丁香油进行包埋形成微胶囊,使其具有一定的缓释性和良好的抗菌效果。方法利用两亲共聚物包埋丁香油形成包合物,采用单因素实验法,以包埋率为指标,评价月桂醇与海藻酸的接枝率对包埋率的影响,并在此基础上评价接枝率对缓释性以及不同环境下的稳定性和抗菌性能。结果在一定范围内包埋率随着接枝率的增大而升高;丁香油微胶囊的挥发率为14.11%,远低于丁香油的挥发率61.25%;释放试验中,丁香油微胶囊的缓释性明显优于未改性海藻酸纳,丁香油微胶囊能稳定缓慢地释放抗菌成分,控制大肠杆菌的生长。结论月桂醇改性海藻酸钠包埋丁香油形成的微胶囊具有一定的缓释和抗菌性能,突破了丁香油因挥发性强而存在的应用限制。

The work aims to form amphiphilic copolymer of laurinol and sodium alginate through graft copolymerization by chemical methods, embed clove oil and then form microcapsules of sustained release and stability in different environments. Amphiphilic copolymer was used to embed clove oil and then form microcapsules. The effect of amphiphilic copolymers graft ratio on encapsulation efficiency was evaluated by using single factor experiment method with the embedding rate as the index. Then its effect on release and stability of microcapsules under different conditions was also evaluated on this basis. Results showed, in a certain range, embedding rate rose with the increase of grafting increases; the volatilization rate of clove oil microcapsule was 14.11%, far below its evaporation rate 61.25%; in release assay, sustained release of clove oil microcapsule was significantly better than unmodified sodium alginate. Clove oil microcapsule could release antibiotic constituents stably and slowly and could control the growth of escherichia coli. In conclusion, clove oil microcapsule that is formed by embedding of modified laurinol and sodium alginate has certain sustained release and mold resistance properties, and expands the scope of application of clove oil.