小檗碱抑制动脉粥样硬化炎性因子作用机制研究进展

Mechanism of berberine inhibiting inflammatory factors in atherosclerosis

目的综述小檗碱抑制动脉粥样硬化炎性因子的作用机制。方法对近年来CNKI、万方数据库及Pubmed中有关小檗碱抑制动脉粥样硬化炎性因子机制的相关文献进行归纳。结果小檗碱属异喹啉类生物碱,是从黄连中提取的主要成分;具有抗血栓、抗平滑肌增殖、保护内皮细胞、抗炎、促血管内皮舒张因子释放及抑制氧化活性等作用;其机制主要表现在调控COX-2的炎性表达、p38MAPK信号、NF-кB活性、VCAM-1与MCP-1表达,调控c-JUN末端激酶信号、ERK活性表达和清除自由基等。结论小檗碱抑制动脉粥样硬化炎性因子的机制研究虽取得一定进展,但仍未明确,需要进一步深入探索。

Objective To review the mechanism of berberine on inhibiting atherosclerosis and provide reference for the development and clinical application of berberine in the future. Methods In recent years,the relevant literatures about CNKI,Wan Fang database and Pubmed in the inhibition of atherosclerosis mechanism of atherosclerosis were summarized. Results Isoquinoline alkaloid berberine,is the main component extracted from Rhizoma Coptidis;has antithrombotic,anti smooth muscle proliferation,protecting endothelial cells,anti-inflammatory,promoting vascular endothelial diastolic factor release and inhibition of oxidative activity; the mechanism mainly in the expression regulation of COX-2 inflammatory,p38 MAPK,NF kappa B activity,VCAM-1 and MCP-1 expression,regulation of c-jun terminal kinase signaling and activity of ERK expression and scavenging free radicals. Conclusion Although it has made some progress in the mechanism of inhibiting the inflammatory factors of atherosclerosis.