摘要
目的探讨利福平在6种溶媒中的稳定性。方法利福平分别和6种溶媒配伍后,采用RP-HPLC法对不同温度及不同时间下的样品含量进行检测。结果利福平在500 m L 0.9%氯化钠注射液和500 m L 5%葡萄糖注射液中的浓度没有显著改变,在其他溶媒中浓度随着温度升高和时间延长均出现了不同程度的下降。结论 500 m L 0.9%氯化钠注射液和500 m L 5%葡萄糖注射液是最适合利福平的溶媒。
Abstract: Objective To investigate the stability of rifampin in six solvents. Methods After the samples of rifampin were dissolved in six solvents, RP-HPLC was employed to analyze the contents at different time and temperature. Results The concentration of rifampin had no significant change in 0.9% NS and 5% GS with the volume of 500 mL. However, the decline of the content of rifampinin was observed with increased temperature and extended time. Conclusion It may be beneficial to make up rifampin in 0.9% NS and 5% GS with the volume of 500 mL.
出处
《中国药物警戒》
2016年第8期500-502,共3页
Chinese Journal of Pharmacovigilance
关键词
利福平
溶媒
配伍稳定性
rifampin
solvent
compatible stability