硝苯地平联合硫酸镁治疗妊娠高血压的疗效观察

Curative effect observation of Nifedipine combined with Magnesium Sulfate on treatment of pregnancy-induced hypertension

目的观察硝苯地平联合硫酸镁治疗妊娠高血压疾病的临床疗效。方法选取礼泉县民源医院收治的妊娠高血压疾病患者中符合标准的100例患者做为研究对象,分为观察组和对照组各50例。对照组给予硫酸镁静脉滴注治疗,观察组在给予硫酸镁静脉滴注治疗的基础上联合口服硝苯地平进行治疗,观察两组治疗后的临床效果。检测患者收缩压和舒张压,比较治疗前后的变化情况;测量两组患者治疗前后尿蛋白水平、血黏度、红细胞压积(PCV)、胎儿脐动脉收缩压与舒张压的比值(S/D)、C反应蛋白(CPR)及CD4+/CD8+变化情况。对两组患者治疗后进行追踪预后,比较产妇及新生儿结局:终止妊娠、自然分娩、早产、新生儿窒息的发生率。结果观察组总有效率为94%,明显高于对照组总有效率74%(P<0.05);治疗后两组患者血压较治疗前有明显降低(P<0.05);观察组比对照组降低更明显,组间比较差异具有统计学意义(P<0.05)。治疗后两组尿蛋白水平均显著下降(P<0.05);观察组尿蛋白水平明显低于对照组(P<0.05)。治疗后两组患者血黏度、PCV、S/D、CPR及CD4+/CD8+都明显改善,与治疗前比较差异显著(P<0.05),且观察组各指标改善情况明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组患者自然分娩率明显高于对照组患者,观察组产妇终止妊娠、早产及新生儿窒息的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论硝苯地平联合硫酸美治疗妊娠高血压疗效明显,具有临床推广价值。

Objective To observe the curative effect of Nifedipine combined with Magnesium Sulfate on the treatment of pregnancy-induced hypertension. Methods Totally 100 cases diagnosed with pregnancy-induced hypertension were selected and divided into observation group and control group randomly, 50 cases in each group. The patients in control group were treated with iv infusion of Magnesium Sulfate. The patients in observation group were given Magnesium Sulfate combined with oral nifedipine. Then the clinical effect of the two groups after treatment were observed. To detect the patient＇s systolic blood pressure and diastolic blood pressure, and compare the changes before and after treatment. The levels of urinary protein, blood viscosity, red blood cell （PCV）, fetal umbilical artery systolic blood pressure and diastolic blood pressure （S/D）, C reactive protein （CPR） and CD4＋/CD8＋ were measured before and after treatment in two groups. After treatment, two groups of patients were followed to prognosis, compared with the maternal and neonatal outcomes, including termination of pregnancy, spontaneous labor, premature birth, and neonatal asphyxia incidence. Results The total effective rate in observation group was 94%, which was significantly higher than that of 74% in control group （P 〈 0.05）. Blood pressure in the two groups after treatment was significantly lower than before treatment （P 〈 0.05）, and that of the observation group was significantly lower than the control group （P 〈 0.05）. After treatment, the levels of urinary protein in the two groups were significantly decreased （P 〈 0.05）; the level of urinary protein in the observation group was significantly lower than that in the control group （P 〈 0.05）. After treatment, blood viscosity, PCV, S/D, CPR and CD4＋/CD8＋ of two groups were significantly improved （P 〈 0.05）, and the observation group, each index improved significantly better than the control group （P 〈 0.05）. After treatment, natural childbirth rate of observation group was significantly higher than that of the control group,maternal termination of pregnancy, premature birth and neonatal asphyxia incidence of observation group was significantly lower than that of the control group, the difference between the two groups has statistical significance （P 〈 0.05）. Conclusion The treatment of Nifedipine combined with Magnesium Sulfate on the patients with pregnancy-induced hypertension shows obvious therapeutic effect, which is worthy of clinical popularization.