介孔分子筛MCM-41固载席夫碱与醋酸锌共催化“一锅法”合成噻唑啉酮衍生物

One-Pot Synthesis of 4-Thiazolidinone Derivatives Catalyzed by Zinc Acetate-Schiff Base Complex Immobilized on Mesoporous Molecular Sieve MCM-41

利用介孔分子筛MCM-41固载席夫碱与Zn(OAc)_2作为催化剂,"一锅法"简单有效地催化了醛、胺和巯基乙酸合成噻唑啉酮衍生物.一系列取代的醛和胺被考察,发现此催化剂能够高效地催化此反应,收率最高可达98%.另外,此类催化剂能够回收再利用,催化循环5次,反应依然可以得到80%的产率.

A new simple and efficient one-pot synthesis of thiazolidinone derivatives via aldehydes, amines and mercaptoacetic acid in the presence of Zn（OAc）2-Schiff base complex immobilized on MCM-41 is described. A variety of aldehydes and amines were engaged in the study and afforded respective thiazolidinones in high yield （up to 98%）. Moreover, consistent activity of recovered catalyst was found to be almost same up to five cycles in 80% yield.