原发性硬化性胆管炎与炎性肠病合并结直肠肿瘤关系的研究进展

Progress for primary sclerosing cholangitis and the risk of colorectal neoplasia in patients with inflammatory bowel disease

原发性硬化性胆管炎(PSC)是一种与炎性肠病(IBD)密切相关的慢性胆汁淤积性肝脏疾病。PSC增加IBD尤其是溃疡性结肠炎患者结直肠肿瘤的发病风险。PSC增加IBD患者结直肠肿瘤的发病机制还未完全阐明。现有预防措施的疗效仍存在争议。每年行结肠镜检查可能会减少结直肠癌变的风险。

Primary sclerosing cholangitis( PSC) is a chronic cholestatic liver disease strongly associated with inflammatory bowel disease( IBD). PSC increases the risk of colorectal neoplasia in patients with IBD,particularly those with ulcerative colitis( UC),but the mechanisms remain unknown. At present,the roles of preventive strategies are controversial. Annual surveillance colonoscopies may decrease cancer risk.