摘要
肝纤维化是各种慢性肝病的共同病理基础,是肝脏细胞外基质(ECM)在肝组织的过度沉积。在肝纤维化发生发展过程中,涉及多种细胞因子的相互作用,其中,基质金属蛋白酶(MMPs)和基质金属蛋白酶抑制剂(TIMPs)与ECM合成与降解密切相关。各种慢性病因作用于肝脏后,MMPs与TIMPs介导的纤维降解平衡被打破,从而导致ECM的过度沉积,最终导致肝脏纤维化。研究MMPs/TIMPs介导的纤维消融平衡,对早期诊断肝纤维化以及逆转肝纤维化有着重要的意义。
Liver fibrosis,with excessive deposition of extracellular matrix( ECM),is a common pathological basis of chronic liver disease. Liver fibrosis procedure includes multi-cytokines,especially matrix metallo preteinases( MMPs) and tissue inhibitor of metalloproteinases( TIMPs),those are associated with the synthesis and degradation of ECM. Duing to a variety of chronic liver diseases,the balance of fibrogenesis and fibrolysis mediated by MMPs / TIMPs is broken,leading to eventually liver fibrosis. Therefore,the study of the balance of fibrogenesis and fibrolysis mediated by MMPs / TIMPs has an important significance to diagnosis of early liver fibrosis and recovery of liver fibrosis.
出处
《中华消化病与影像杂志（电子版）》
2016年第4期175-179,共5页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
纤维化
肝
基质金属蛋白酶类
基质金属蛋白酶抑制剂
细胞外基质
Fibrosis,liver
Matrix metalloproteinases
Tissue inhibitor of metalloproteinase
Extracellular matrix
