肺部铜绿假单胞菌(PAE)感染患者前后肺角质细胞生长因子(KGF)的变化

Changes of keratinocyte growth factor level before and after pulmonary Pseudomonas aeruginosa infection

目的:探讨患者在肺部铜绿假单胞菌(PAE)感染前后肺角质细胞生长因子(KGF)的变化情况。方法:选取肺炎患者62例为观察对象,对其PAE感染前后肺组织进行检测,观察其KGF水平变化情况。结果:对本组患者进行免疫印迹定量测试后,结果表明,所有患者在PAE感染后,肺组织KGF蛋白表达水平同感染前对比,明显较高,差异存在统计学意义(P<0.05),且随时间推移,患者KGF表达水平呈较明显上升趋势,在72 h后,KGF值达到最高水平。本组患者中PAE感染前,肺组织KGF蛋白含量较为稳定,PAE感染后各时间段,患者肺组织KGF含量均明显高于感染前,差异存在统计学意义(P<0.05)。结论:在PAE感染后,患者肺组织KGF水平会出现明显变化,随病程发展而增长。对KGF水平进行严密监测,同时采取辅助干预措施,能有效改善症状,促进患者痊愈。

Objective To investigate changes of keratinocyte growth factor （ KGF） level before and afterpulmonar Pseudo-monas aeruginosa （ PAE ） infection. Methods ： 62 pneumonia patients were sele cted , and their lung tissues before and afterPAE infec-tion were detected to obsere the changes of the KGF levels. Results ： The immunoblot quantitative testing for this group of patients showed that the expression level of KGF protein after PAE infection was significantly higher than that before PAE infection, and the difference was statistically significant （P 〈0. 05）. Over tim e, the expression level of KGF showed a rising trend and reached to the highest after 72 h . The content of KGF protein was relatively stable before PAE infection, while after PAE infect ion, the value at each time period was obviously higher than those before PAE infection, and the differences were statistically significant （P 〈0. 05 ）. Conclu-sions ：After PAE infection, the level of KGF in the lung tissue of the patients will appear obvious ch ang e, and increase with the course. Therefore, the strict monitoring of KGF as well as assisted interventions can be effective in improving symptoms and promote the patients＇ recovery.