脑梗死出血性转化的危险因素分析

Analysis of risk factors for hemorrhagic transformation of cerebral infarction

目的探讨影响脑梗死出血性转化（HT）的危险因素。方法选取2010年-3月到2014年5月在本院住院治疗的238例急性脑梗死患者作为研究对象,根据有无HT分为HT组（34例）和非HT组（204例）。比较两组的临床指标,筛选影响急性HT的因素。结果 HT组的脑梗死、高血压、吸烟、饮酒、糖尿病、冠心病、心房颤动、大面积脑梗死发生率及空腹血糖、纤维蛋白原、C3、CRP水平显著高于非HT组,差异有统计学意义（P〈0.05）。Logistic回归分析显示,糖尿病、心房颤动、高血压、大面积脑梗死、CRP和C3是急性脑梗死HT的独立危险因素。结论糖尿病、心房颤动、高血压、大面积脑梗死、CRP及C3是急性HT的独立危险因素。

Objective To explore the risk factors for hemorrhagic transformation（HT） of cerebral infarction.Methods238 patients with acute cerebral infarction in our hospital from March 2010 to May 2014 were selected and divided into the HT group（34 cases） and the non-HT group（204 cases） according to whether or not combined with HT.Clinical indicators was compared between the two groups,the factors that affected acute HT were screened.Results The incidence rate of cerebral infarction,hypertension,somking,drinking,diabetes mellitus,coronary heart disease,atrial fibrillation,massive cerebral infarction and the level of fasting glucose,fibrinogen,complement 3（C3）,CRP in the HT group was higher than that in the non-HT group,with significant difference（P〈0.05）.The results of multivariate Logistic regression analysis revealed that diabetes mellitus,atrial fibrillation,hypertension,massive cerebral infarction,CRP and C3 were independent risk factors for HT after acute cerebral infarction.Conclution Diabetes mellitus,atrial fibrillation,hypertension,massive cerebral infarction,CRP and C3 are the independent risk factors for HT after acute cerebral infarction.