高通量血液透析与高通量血液透析滤过对慢性肾病患者骨及矿物质代谢的影响分析

Influence analysis of high flux hemodialysis and high flux hemodialysis filtration on bone and mineral metabolism of chronic kidney disease patient

目的探讨高通量血液透析与高通量血液透析滤过对患者骨及矿物质代谢的影响。方法选取2013年10月-2015年10月本院收治的75例慢性肾病患者作为研究对象,随机分为对照组（38例）和观察组（37例）。对照组给予高通量血液透析治疗,观察组给予高通量血液透析滤过治疗。比较两组治疗前后的尿素氮（BUN）、血肌酐（Scr）、白蛋白（ALB）、血钙、血磷以及甲状旁腺激素水平。结果两组治疗1、6个月后的BUN、Scr水平显著低于治疗前,ALB水平显著高与治疗前,差异有统计学意义（P〈0.05）。两组治疗后的BUN、Scr、ALB水平比较,差异无统计学意义（P〉0.05）。两组治疗1个月后的血钙、血磷以及甲状旁腺激素水平比较,差异无统计学意义（P〉0.05）。观察组治疗6个月后的血钙水平高于对照组,血磷及甲状旁腺激素水平显著低于对照组,差异有统计学意义（P〈0.05）。结论高通量血液透析与高通量血液透析滤过均能明显改善慢性肾脏病患者的肾功能以及骨、矿物质代谢,相比而言,高通量血液透析滤过效果更佳。

Objective To explore the influence of high flux hemodialysis and high flux hemodialysis filtration on bone and mineral metabolism of chronic kidney disease patient.Methods 75 patients with chronic kidney disease from October 2013 to October 2015 in our hospital were selected and randomly divided into the control group（38 cases） and the observation group（37 cases）.The control group was given high flux hemodialysis,the observation group was given high flux hemodialysis filtration.The level of BUN,Scr,ALB,blood calcium,Blood phosphorus and parathyroid hormone before and after treatment in the two groups was compared.Results The level of BUN,Scr after treatment for 1,6 months in the two groups was lower than that before treatment,the level of ALB after treatment for 1,6 months in the two groups was higher than that before treatment,with significant difference（P〈0.05）.There was no significant difference in the level of BUN,Scr,ALB after treatment between the two groups（P〈0.05）.There was no significant difference in the level of blood calcium,blood phosphorus and parathyroid hormone after treatment for 1 month between the two groups（P〈0.05）.The level of blood calcium after treatment for 6 months in the observation group was higher than that in the control group,the level of blood phosphorus and parathyroid hormone after treatment for 6 months in the observation group was lower than that in the control group,with significant difference（P〈0.05）.Conclusion Both of high flux hemodialysis and high flux hemodialysis filtration can obvious improve renal function and bone and mineral metabolism of patients with chronic kidney disease.In comparison,the effect of high flux hemodialysis filtration is better.