初治和复治肺结核合并肺部感染的临床分析

Clinical analysis of initial and recurrent pulmonary tuberculosis combined pulmonary infection patient

目的探讨初治和复治肺结核合并肺部感染患者的病原菌分布状况和临床耐药特征。方法研究初治和复治肺结核合并肺部感染患者送检痰标本的细菌培养结果,观察患者的耐药性,结果初治和复治肺结核合并肺部感染患者以革兰阴性菌为主,复治组为59.47%,初治组为52.87%;复治组革兰阳性菌为21.20%,初治组为27.38%;复治组真菌19.33%,初治组19.75%;复治组细菌对左氧氟沙星、莫西沙星及利福平的耐药率较初治组有显著的增加。结论复治肺结核患者的反复治疗导致细菌耐药性增强。

Objective To discuss the pathogenic bacteria distribution and drug resistance of clinical features of initial and recurrent pulmonary tuberculosis infection patients. Methods Studied the bacterial culture results of sputum speci- mens by initial treat and retreat pulmonary tuberculosis infection patients with pulmonary infection were and observed drug resistance of patients. Results Initial and recurrent pulmonary tuberculosis patients with pulmonary infection were mainly gram -negative bacteria, group was 59. 47%, the initial treated group is 52. 87% ; Recurrent group of gram - positive bacteria was 21.20% , the initial treated group is 27.38% , fungi of recurrent group is 19. 33% and initial group 19.75%; The recurrent group bacteria has increase drug tolerance to levofloxacin, moxifloxacin and rifampicin than initial treats. Conclusion The treatment repeatedly of recurrent pulmonary tuberculosis infection patients lead to bacterial resistance increased.