双眼相位整合平衡点检测在单眼弱视患者眼间抑制定量评估中的应用

Application of the binocular phase combination paradigm in quantifying interocular suppression in amblyopia

目的 采用双眼相位整合的测量范式定量评估单眼弱视患者的眼间抑制情况，并探讨患者眼间抑制度与其他视功能的相关性。方法 前瞻性临床对照研究。收集在安徽医科大学第一附属医院眼科门诊就诊的未治疗过的单眼弱视患者51例，正常对照者25例，采用计算机程序呈现的双眼整合的测量范式进行双眼相位整合平衡点检测，比较单眼弱视患者和正常对照者双眼平衡点的差异，并将弱视患者检测结果与弱视眼视力、立体视锐度及屈光参差程度进行相关性分析。结果 弱视组双眼平衡点（BP）值为0.227±0.016，正常对照组BP值为0.984±0.020，两组间差异有统计学意义（t=27.316，P〈0.01）；弱视眼视力（r=-0.339，P〈0.05）、立体视功能（Titmus：r=-0.421，P〈0.01；RDS：r=-0.548，P〈0.01；Fishy：r=-0.553，P〈0.01）与BP值之间均存在显著的相关关系，屈光参差程度与BP值之间无明显相关性（r=-0.086，P〉0.05）。结论 双眼相位整合平衡点检测可定量评估弱视患者弱视眼的受抑制程度，有一定的临床应用前景。

Objective To evaluate the application of the binocular phase combination paradigm in quantifying interocular suppression in amblyopia, and to further assess the correlation between interocular suppression and visual deficits in amblyopia. Methods This was a cross-sectional study. Twenty-five normal controls and 51 patients with monocular amblyopia who had no prior treatment were included in this study. A binocular phase combination paradigm was used to examine an individual′s balance point when the two eyes were equally effective. The correlation between balance points and visual deficits, including the visual acuity of the amblyopic eye, stereoacuity and the degree of anisometropia were studied. Results The average balance point of the amblyopic group was 0.227±0.016, far lower than that in normal subjects （0.984±0.020）, and the difference was statistically significant （t=27.316, P〈0.01）. There was a significant correlation between the balance point and the visual acuity of the amblyopic eye （r=-0.339, P〈0.05）, and between the balance point and stereoacuity （Titmus： r=-0.421, P〈0.01; RDS： r=-0.548, P〈0.01; Fishy： r=-0.553, P〈0.01）. However, no significant correlation was found between the balance point and the degree of anisometropia （r=-0.086, P〉0.05）. Conclusion A binocular phase combination paradigm can provide a quantitative measure of the binocular status of amblyopia, which is useful in clinical binocular examinations.