炔基胺大环为模板高阶组装构筑的螺旋溶剂通道

Spiral Solvent Channel Based on the Building Block Assembly of Propargylamine Macrocycle

以双位点端基炔、哌嗪和甲醛为底物,在一价铜盐的催化作用下,一步实现含有炔基胺骨架大环产物的构建。产物通过了1H NMR、13C NMR、IR和HRMS等测试手段的表征,且得到了X-ray单晶衍射的直接证实。进一步研究基于该大环产物为组装单元,借助弱氢键作用力构筑超分子手性螺旋结构,重点研究其高阶堆积结构特征。以氢键为驱动力,来构建一些特殊的自组装形态:实现由非手性分子高阶组装表现出超分子手性这一特殊现象,有望实现在信息、材料、生物等前沿领域的应用。

The two-site terminal alkyne, piperazine and its derivatives, and formaldehydes as substrates were used to achieve the construction of alkynelymine macrocyclic product in the presence of catalysis of Cu （ I） Salt.The product was characterized by the ^1H NMR, ^13C NMR, IR and HRMS, and has been directly confirmed by X-ray single crystal diffraction.Based on the macro-cyclic product as assembly unit, we build supramolecular chiral helical structure by using the weak hydrogen bonding force, and mainly study its high-end packing structure feature.The driving force of self-assembly mainly involves hydrogen bonding force, and form some special self-assembled morphology： to achieve the particular phenomenon of supramolecular chiral high-end assembled by non-chiral molecules.It is expected to achieve the application in cutting-edge fields such as in the field of information, materi-als and biological.