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Cancer/testis antigens and obligate participation in multiple hallmarks of cancer： an update 被引量：1

Cancer/testis antigens and obligate participation in multiple hallmarks of cancer： an update
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摘要 The Cancer/Testis Antigens （CTAs） are a group of so-called tumor antigens that exhibit provocative expression patterns in most types of cancer. However, because most CTAs appear to be intrinsically disordered, they are recalcitrant to classical structural studies. The Cancer/Testis Antigens （CTAs） are a group of so-called tumor antigens that exhibit provocative expression patterns in most types of cancer. However, because most CTAs appear to be intrinsically disordered, they are recalcitrant to classical structural studies.
作者 Steven M Mooney Krithika Rajagopalan Govindan Rangarajan Prakash Kulkarni
机构地区 Department of Biology Department of Biological Sciences Department of Mathematics and Centre for Neuroscience Institute for Bioscience and Bietechnology Research
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2016年第5期711-712,共2页 亚洲男性学杂志（英文版）
分类号 Q784 [生物学—分子生物学] Q492.4 [生物学—生理学]
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参考文献12

  • 1Simpson A J, Caballero OL, Jungbluth A, Chen YT, Old LJ. Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 2005; 5: 615-25.
  • 2Maxfield KE, Taus P J, Corcoran K, Wooten J, Macion J, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun 2015;6: 8840.
  • 3Rajagopalan K, Mooney SM, Parekh N, Getzenberg RH, Kulkarni P. A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem 2011; 112: 3256-67.
  • 4Rajagopalan K, Qiu R, Mooney SM, Rao S, Shiraishi T, etal. The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation. Biochim Biophys Acta 2014; 1842: 154-63.
  • 5Mooney SM, Qiu R, Kim J J, Sacho E J, Rajagopalan K, et al. Cancer/testis antigen PAGE4, a regulator of c-Jun trensactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. Biochemistry2014; 53: 1670-9.
  • 6He Y, Chen Y, Mooney SM, Rajagopalan K, Bhargava A, et al. Phosphorylatien-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen. J Biol Chem 2015; 290: 25090-102.
  • 7Bah A, Vernon RM, Siddiqui Z, Krzeminski M,Muhandiram R, et al. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature 2015; 519: 106-9.
  • 8Vavouri T, Sempe Jl, Garcia-Verdugo R, Lehner B. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Cell 2009; 138: 198-208.
  • 9Mahmoudabadi G, Rajagopalan K, Getzenberg RH, Hannenhalli S, Rangarajan G, et al. Intrinsically disordered proteins and conformational noise: implications in cancer. CelI Cycle 2013; 12: 26-31.
  • 10Eldar A, Elowitz MB. Intrinsically disordered proteins and conformational noise: implications in cancer. Nature 2010; 467: 167-73.

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Asian Journal of Andrology
2016年 第5期

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