降钙素原、C-反应蛋白在细菌感染性肺炎诊断和预后中的价值

Diagnosis and prognosis value of C-reactive protein and procalcitonin for bacteria infectious pneumonia

目的探讨降钙素原(PCT)、C-反应蛋白(CRP)对儿童细菌感染性肺炎的早期诊断和预后判断的价值。方法选择在本院接受治疗的70例细菌感染性肺炎儿童为细菌感染组,选取70例非细菌感染性肺炎儿童为非细菌感染组,另取70例健康儿童为非感染组。收集各组患儿痰液进行培养,于治疗前测定3组儿童C-反应蛋白(CRP)水平及白细胞计数(WBC)、血沉(ESR)等炎性指标。结果细菌感染性肺炎患儿PCT和CRP含量明显高于非细菌感染性肺炎组和非感染组(P<0.05),细菌感染性肺炎组患儿CRP及PCT含量在痰培养阳性组中的表达量显著高于痰培养阴性组(P<0.05),细菌感染性肺炎患儿治愈组入院时CRP及PCT含量明显低于未治愈组(P<0.05)。结论 CRP及PCT能在一定程度上早期诊断儿童细菌感染性肺炎并预测痰培养结果及治疗结局,具有一定的临床价值。

Objective To explore the clinical value of C-reactive protein and procalcitonin for bacteria infectious pneumonia in children.Methods A total of 70 children with bacterial infectious pneumonia,70 children with non-bacteria infectious pneumonia and 70 children with non-infectious disease were selected as the bacterial infectious pneumonia group,the non-bacterial infectious pneumonia group and the non-infectious disease group respectively.Sputum collected from the children in three groups were cultured for the detection of PCT,CRP,WBC counts and ESR levels before treatment.Results PCT and CRP levels of bacterial infectious group were significantly higher than other two groups（P〈0.05）.As for children with bacterial infectious group,CRP and PCT levels of sputum culture positive were higher than those children with sputum culture negative（P〈0.05）.As for children with bacterial infectious group,CRP and PCT levels of curative group was lower than those children in non-curative group（P〈0.05）.Conclusion CRP and PCT can be a good index for early diagnosing bacterial pneumonia in children and predicting the sputum culture results and treatment outcome,so it has a certain clinical value.