温州市9346例孕前和孕早期女性巨细胞病毒与风疹病毒感染状况调查

Investigation on cytomegalovirus and rubella virus infection in 9 346 cases during progestation and early pregnancy in Wenzhou

目的分析温州市孕前及孕早期妇女风疹与巨细胞病毒的感染状况,为制定孕前及孕早期保健措施提供参考。方法 2011年12月-2014年12月,累计对9 346例孕前检查和孕早期建卡的女性开展风疹病毒lg G和IgM,巨病毒IgG和IgM抗体检测。分析孕前和孕早期女性巨细胞病毒与风疹病毒感染率。结果本次研究结果的巨细胞病毒的总体易感率为4.23%,不同年龄段间易感率差异无统计学意义（χ^2=3.67,P〉0.05）。不同年龄段对象风疹的易感率差异有统计学意义（χ^2=32.34,P〈0.01）,年龄在35岁-39岁易感率最高,为22.53%。结论温州市育龄期妇女巨细胞病毒易感率较低,风疹病毒率较高,在不同年龄段差异明显,应加强对高危年龄段孕妇的筛查。对于筛查结果为Ig M阳性的孕妇应采取羊水、脐血或绒毛组织进行胎儿宫内感染的产前诊断。

Objective To evaluate the infection of rubella virus and cytomegalovirus during progestation and early pregnancy in Wenzhou so as to provide basis for the formulation of pregnancy and early pregnancy care measures.Methods From December 2011 to December 2014,we checked Ig G and Ig M of rubella virus and cytomegalovirus in 9 346 women with inform consent during antenatal care or in the first trimester.We make an analysis on the infection rate ofrubella virus and cytomegalovirus in women during progestation and early pregnancy.Results The overall susceptibility prevalence of cytomegalovirus was 4.23%,and there was no statistical significance on the differences among different age groups（χ^2= 3.67,P〉0.05）.There was statistical significance on the differences in rubella susceptibility among different age groups（χ^2= 32.34,P〈0.01）,and the highest prevalence was 22.53% in the 35-40 years old group.Conclusion The susceptibility of cytomegalovirus was low.The susceptibility of rubella virus was higher,and showed large differences in different age groups.Carrying out routine screening for rubella virus in aged pregnant women is necessary.We should take the amniotic fluid,umbilical cord blood and fetal villi to carry out prenatal diagnosis of fetal intrauterine infection for pregnant women with positive Ig M.