酸枣仁汤联合氟哌噻吨美利曲辛与谷维素治疗围绝经期抑郁随机平行对照研究

Suanzaoren Decoction(酸枣仁汤) combined with Flupentixol and Melitracen Tablets and Oryzanol in the Treatment of Perimenopausal Depression Randomized Controlled Study

[目的]观察酸枣仁汤联合氟哌噻吨美利曲辛与谷维素治疗围绝经期抑郁疗效。[方法]使用随机平行对照方法,将60例门诊患者按抛硬币方法简单随机分为两组。对照组30例氟哌噻吨美利曲辛,0.5mg/次,2次/d,口服;谷维素,10mg/次,3次/d,口服。治疗组30例酸枣仁汤(酸枣仁30g,川芎、茯苓、知母12g,甘草6g;肝郁化火加栀子、牡丹皮;痰热内扰加黄连、瓜蒌、栀子;阴虚火旺加旱莲子、女贞子、百合、地黄;气虚血少,血不养心合炙甘草汤),1剂/d,水煎400m L,2次/d;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、HAMD评分、不良反应。治疗1疗程(15d),判定疗效。[结果]治疗组痊愈8例,显效10例,有效11例,无效1例,总有效率96.67%;对照组痊愈4例,显效8例,有效9例,无效9例,总有效率70.00%;治疗组疗效优于对照组(P<0.05)。HAMD评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]酸枣仁汤联合氟哌噻吨美利曲辛与谷维素治疗围绝经期抑郁,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the Suanzaoren Decoction Combined with Flupentixol and melitraeen tablets and oryzanol in the treatment of perimenopausal depression effect. [Methods] 60 outpatients were randomly divided into two groups according to the method of random parallel control The control group of 30 cases of Flupentixol and melitracen tablets, 0.5 mg/times, 2 times/d, oral; oryzanol, 10 mg/times, 3 times/ d, oral. Treatment group, 30 cases of Suanzaoren Decoction （Suanzaoren 30g, Szechuan ]ovage rhizome, Poria, Anemarrhena 12 g, licorice 6 g; liver depression of the fire add gardenia, cortex moutan; phlegm heat disturbance and Rhizoma Coptidis, Trichosanthes, gardenia; Yin deficiency and fire wangka dry lotus seed, Ligustrum lucidum, Lily and Rehmannia glutinosa; due to deficiency of Qi and blood, blood Yangxin sunburn and licorice）, daily 1 agent, water to cook 400 ml, 2 times daily; western medicine in the treatment of with the control group. Continuous treatment for 1 courses of 15 d. Observation of clinical symptoms, HAMD score, adverse reaction. Treatment of 1 courses of treatment （15 d）, determine the efficacy. [Results] The treatment group, 8 cases recovered, 10 cases were markedly effective, 11 cases were effective, 1 case ineffective, effective rate is 96.67%; control group, 4 cases were cured, 8 cases were markedly effective, 9 cases were effective, 9 cases ineffective, efficient 70.00%. The treatment group curative effect surpasses the control group （P〈0.05）. HAMD score of two groups were improved （P〈0.01）, the treatment group improved better than the control group （P〈0.01）. [Conclusion] Suanzaoren Decoction Combined with droperidol thiadiazole tons and deanxit and oryzanol treatment of perimenopausal depressive disorder, and the results were satisfactory. No serious adverse reactions, worthy of promotion.