龟鹿二仙汤与复方阿胶浆治疗乳腺癌化疗骨髓抑制

To Investigate the Guilu Erxiantang(龟鹿二仙汤) and Fufang Ajiao Jiang(复方阿胶浆) Treatment of Breast Cancer Chemotherapy Bone Marrow Suppression

乳腺癌化疗导致骨髓抑制,外周血白细胞计数降低,皮下注射重组人粒细胞刺激因子可快速刺激骨髓产生白细胞,但疗效短,价格昂贵,且存在不良反应。现代研究证明中药有效成分提取物均具有一定抗肿瘤作用,以龟鹿二仙汤、复方阿胶浆为代表的复方制剂效果更为明显,但其作用机制尚不清楚。补气养血是治疗乳腺癌化疗致骨髓抑制的主要方法,常用药物中几乎都含有保护骨髓、升高白细胞、抗肿瘤作用的成分,但无论方剂是用汤剂、散剂或者丸剂,不会产生严重副作用,但起效慢,影响化疗后白细胞恢复。目前尚缺乏统一诊疗标准,难以推广使用,未来对辨证分型、病因病机、诊断、预防和治疗等仍需不断努力和完善,将药物中保护骨髓和抗肿瘤的成分提取出来,以达快速且安全有效效果。

Breast cancer chemotherapy means leads to inhibition of bone marrow, peripheral white blood cell count decreased, subcutaneous injection of recombinant human granulocyte colony-stimulating factor injection can rapidly stimulate the bone marrow to produce white blood ceils, but the effect is short, expensive, and there adverse reactions. Modern research that extracts effective ingredients of Chinese medicine had certain antitumor effect and in Guilu Erxian Tang and Fufang Ajiao Jiang as the representative of the compound effect is more obvious. Qi and blood is the main method of bone marrow suppression caused by chemotherapy in breast cancer treatment, commonly used drugs in almost all contain protected bone marrow, elevated white blood cell, anti-tumor effect of the ingredients, but whether it is prescription decoction, powder or pill, no serious side effects, but the slow onset, white blood cell recovery after chemotherapy. But the mechanism is not clear, lack of unified standard of diagnosis and treatment, is difficult to generalize, the future of the syndrome differentiation typing, etiology and pathogenesis, diagnosis, prevention and treatment of still need continuous efforts and finish, drug in protecting marrow and antitumor constituents of the extract, to the effect of fast, safe and effective.