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^(125)I粒子植入联合化疗治疗早期非小细胞肺癌的疗效分析

Effects of combined ^(125)I seeds implantation and chemotherapy in early stage of non-small cell lung cancer
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摘要 目的观察^(125)I粒子植入术联合化疗治疗早期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效。方法选取不接受手术的39例Ⅰ、Ⅱ期NSCLC患者。分为单纯化疗组19例及^(125)I粒子植入治疗联合化疗组20例。联合治疗组化疗前给予CT引导下经皮^(125)I粒子植入术1次,所有患者按吉西他滨+顺铂方案化疗3次。6个月后查胸部CT。结果 6个月后,单纯化疗组中完全缓解率(CR)5.26%(1/19),部分缓解率(PR)52.63%(10/19),无变化(NC)21.05%(4/19),进展(PD)21.05%(4/19),总有效率57.89%,局部控制率78.95%;联合治疗组CR20%(4/20),PR 70%(14/20),NC 10%(2/20),PD 0,总有效率90%,局部控制率100%。联合治疗组的总有效率及局部控制率均高于单纯化疗组,差异有统计学意义(P<0.05)。结论对于不能接受手术的早期NSCLC,CT引导下经皮^(125)I粒子植入术联合化疗局部控制率高、近期疗效好、创伤小,是一种有效的治疗方法。 Objective To evaluate the effects of 125I seeds implantation combined chemotherapy in early stage of non-small cell lung cancer( NSCLC). Methods Totally 39 inoperable early stage NSCLC patients were divided into two groups,the simple chemotherapy group( n = 19) and 125I seeds implantation combined chemotherapy( n = 20). The combined group proceeded with CT guided percutaneous implantation of 125I seeds before chemotherapy. All patients received GP( gemcitabine + cisplatin) chemotherapy with total 3 cycles. The chest CT detection was performed at 1,3,6months. The clinical effects were evaluated after 6 months. Results In simple chemotherapy group,the complete remission( CR),partial remission( PR),no change( NC),progressive disease( PD),the total effective rate,local control rate were 5. 26%( 1 /19),52. 63%( 10 /19),21. 05%( 4 /19),21. 05%( 4 /19),57. 89%,78. 95%,respesctively. In combined group,CR,PR,NC,PD,the total effective rate,local control rate were 20%( 4 /20),70%( 14 /20),10%( 2 /20),0%,90%,100%,respesctively. The total effective rate and local control rate in combined group were higher than simple group( P 〈 0. 05). Conclusion The treatment of 125I seeds implantation combined chemotherapy had higher local control rate,short- term effects and mild injury for early stage NSCLC.
作者 林香花 时军
出处 《医药论坛杂志》 2016年第2期60-61,64,共3页 Journal of Medical Forum
关键词 非小细胞肺癌 粒子植入术 化疗 Non-small cell lung cancer 125I seeds implant brachytherapy Chemotherapy
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