2型糖尿病并发冠心病患者血清游离脂肪酸及超敏CRP水平的分析

Analysis on serum concentrations of FFA and hs-CRP for T2DM patients complicated with CHD

目的探讨血清游离脂肪酸(FFA)及超敏C反应蛋白(hs-CRP)水平与2型糖尿病(T2DM)并发冠心病(CHD)的相关性。方法选取该院2011年1月至2014年12月收治的80例CHD并发T2DM(CHD+T2DM)的患者及同期收治的单纯T2DM患者80例。测定两组患者血清葡萄糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、hs-CRP和FFA水平。根据患者的血管狭窄程度将CHD+T2DM患者分为单支病变(SVD)和多支病变(MVD)组,比较不同严重程度的患者上述5项指标水平的差异,并且采用Logistic回归分析其与CHD的相关性。结果 T2DM+CHD组患者FPG、TC、TG、hs-CRP和FFA水平高于T2DM组(P<0.01);MVD组FPG、TC、TG、hs-CRP和FFA水平高于SVD组(P<0.01);Logistic分析表明,hs-CRP和FFA为T2DM+CHD的相关因素(P<0.05)。结论 FFA和hs-CRP水平与T2DM患者并发CHD相关,临床治疗需要重点关注。

Objective To investigate the correlation between serum free fatty acid （FFA） and high sensitive C reactive protein （hs-CRP） levels in patients with type 2 diabetes mellitus（T2DM） complicated with coronary heart disease（CHD）. Methods 80 T2DM＋CHD patients treated in the hospital from January 2011 to December 2014 were enrolled in the study,and 80 patients with T2DM alone were also recruited during the same period as control. Serum levels of glucose（FPG） ,total cholesterol （TG） ,total cho- lesterol（CRP） ,total cholesterol（TC）,hs CRP and FFA were measured in the two groups of patients. According to the degree of vascular stenosis in patients with CHD＋T2DM, patients were divided into two groups,single vascular disease（SVD） and multiple vascular disease（MVD）group. Compare the difference of the above 5 indicators in patients with different severity, and use Logistic regression to analyze the correlation between those indicators and CHD. Results The levels of FFA, TC,TG,hs-CRP and FPG in T2DM＋CHD group were higher than those in T2DM group（P〈0.01）. The levels of FPG,TC,TG,hs-CRP and FFA in MVD group were higher than those in group SVD（P〈0.01）. Logistic analysis showed that hs-CRP and FFA were related factors for T2DM＋CHD（P〈0.05）. Conclusion FFA and hs-CRP levels were related with the development of CHD in T2DM patients which the clinical treatment needs to focus on.